Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat
Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adap...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Springer Nature
2018
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| _version_ | 1797095770690682880 |
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| author | Zepeda Mendoza, M Xiong, Z Escalera-Zamudio, M Runge, A Thézé, J Streicker, D Frank, H Loza-Rubio, E Liu, S Ryder, O Samaniego Castruita, J Katzourakis, A Pacheco, G Taboada, B Löber, U Pybus, O Li, Y Rojas-Anaya, E Bohmann, K Carmona Baez, A Arias, C Liu, S Greenwood, A Bertelsen, M White, N Bunce, M Zhang, G Sicheritz-Pontén, T Gilbert, M |
| author_facet | Zepeda Mendoza, M Xiong, Z Escalera-Zamudio, M Runge, A Thézé, J Streicker, D Frank, H Loza-Rubio, E Liu, S Ryder, O Samaniego Castruita, J Katzourakis, A Pacheco, G Taboada, B Löber, U Pybus, O Li, Y Rojas-Anaya, E Bohmann, K Carmona Baez, A Arias, C Liu, S Greenwood, A Bertelsen, M White, N Bunce, M Zhang, G Sicheritz-Pontén, T Gilbert, M |
| author_sort | Zepeda Mendoza, M |
| collection | OXFORD |
| description | Adaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles. |
| first_indexed | 2024-03-07T04:32:40Z |
| format | Journal article |
| id | oxford-uuid:cedc2093-981e-4e98-976b-0b9b8613d5ab |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:32:40Z |
| publishDate | 2018 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:cedc2093-981e-4e98-976b-0b9b8613d5ab2022-03-27T07:38:32ZHologenomic adaptations underlying the evolution of sanguivory in the common vampire batJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cedc2093-981e-4e98-976b-0b9b8613d5abEnglishSymplectic Elements at OxfordSpringer Nature2018Zepeda Mendoza, MXiong, ZEscalera-Zamudio, MRunge, AThézé, JStreicker, DFrank, HLoza-Rubio, ELiu, SRyder, OSamaniego Castruita, JKatzourakis, APacheco, GTaboada, BLöber, UPybus, OLi, YRojas-Anaya, EBohmann, KCarmona Baez, AArias, CLiu, SGreenwood, ABertelsen, MWhite, NBunce, MZhang, GSicheritz-Pontén, TGilbert, MAdaptation to specialized diets often requires modifications at both genomic and microbiome levels. We applied a hologenomic approach to the common vampire bat (Desmodus rotundus), one of the only three obligate blood-feeding (sanguivorous) mammals, to study the evolution of its complex dietary adaptation. Specifically, we assembled its high-quality reference genome (scaffold N50 = 26.9 Mb, contig N50 = 36.6 kb) and gut metagenome, and compared them against those of insectivorous, frugivorous and carnivorous bats. Our analyses showed a particular common vampire bat genomic landscape regarding integrated viral elements, a dietary and phylogenetic influence on gut microbiome taxonomic and functional profiles, and that both genetic elements harbour key traits related to the nutritional (for example, vitamin and lipid shortage) and non-nutritional (for example, nitrogen waste and osmotic homeostasis) challenges of sanguivory. These findings highlight the value of a holistic study of both the host and its microbiota when attempting to decipher adaptations underlying radical dietary lifestyles. |
| spellingShingle | Zepeda Mendoza, M Xiong, Z Escalera-Zamudio, M Runge, A Thézé, J Streicker, D Frank, H Loza-Rubio, E Liu, S Ryder, O Samaniego Castruita, J Katzourakis, A Pacheco, G Taboada, B Löber, U Pybus, O Li, Y Rojas-Anaya, E Bohmann, K Carmona Baez, A Arias, C Liu, S Greenwood, A Bertelsen, M White, N Bunce, M Zhang, G Sicheritz-Pontén, T Gilbert, M Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat |
| title | Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat |
| title_full | Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat |
| title_fullStr | Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat |
| title_full_unstemmed | Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat |
| title_short | Hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat |
| title_sort | hologenomic adaptations underlying the evolution of sanguivory in the common vampire bat |
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