Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger.
The neuropeptides orexins/hypocretins are essential for normal wakefulness and energy balance, and disruption of their function causes narcolepsy and obesity. Although much is known of the role of orexins in sleep/wake behavior, it remains unclear how they stimulate feeding and metabolism. One of th...
Main Authors: | Burdakov, D, Liss, B, Ashcroft, F |
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Formato: | Journal article |
Idioma: | English |
Publicado em: |
2003
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