Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium--calcium exchanger.

The neuropeptides orexins/hypocretins are essential for normal wakefulness and energy balance, and disruption of their function causes narcolepsy and obesity. Although much is known of the role of orexins in sleep/wake behavior, it remains unclear how they stimulate feeding and metabolism. One of th...

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Detalhes bibliográficos
Principais autores: Burdakov, D, Liss, B, Ashcroft, F
Formato: Journal article
Idioma:English
Publicado em: 2003