Optical detection of the anesthetic agent propofol in the gas phase.
The anesthetic agent propofol (2,6-diisopropylphenol) is the most widely used intravenously administered drug in general anesthesia. However, a viable online capability to monitor metabolized levels of propofol in patients does not currently exist. Here we show for the first time that optical spectr...
| প্রধান লেখক: | , , , , , , , |
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| বিন্যাস: | Journal article |
| ভাষা: | English |
| প্রকাশিত: |
2011
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| _version_ | 1826297529069731840 |
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| author | Laurila, T Sorvajärvi, T Saarela, J Toivonen, J Wheeler, D Ciaffoni, L Ritchie, G Kaminski, C |
| author_facet | Laurila, T Sorvajärvi, T Saarela, J Toivonen, J Wheeler, D Ciaffoni, L Ritchie, G Kaminski, C |
| author_sort | Laurila, T |
| collection | OXFORD |
| description | The anesthetic agent propofol (2,6-diisopropylphenol) is the most widely used intravenously administered drug in general anesthesia. However, a viable online capability to monitor metabolized levels of propofol in patients does not currently exist. Here we show for the first time that optical spectroscopy has good potential to detect metabolized propofol from patients' exhaled breath. We present quantitative absorption measurements of gas phase propofol both in the ultraviolet and middle-infrared spectral regions. We demonstrate that a detection limit in the subparts-per-billion concentration range can be reached with photoacoustic spectroscopy in the UV spectral region, paving the way for the development of future optical monitors. |
| first_indexed | 2024-03-07T04:33:01Z |
| format | Journal article |
| id | oxford-uuid:cef83d0d-c8af-429e-a558-640d7d077513 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:33:01Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:cef83d0d-c8af-429e-a558-640d7d0775132022-03-27T07:39:14ZOptical detection of the anesthetic agent propofol in the gas phase.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cef83d0d-c8af-429e-a558-640d7d077513EnglishSymplectic Elements at Oxford2011Laurila, TSorvajärvi, TSaarela, JToivonen, JWheeler, DCiaffoni, LRitchie, GKaminski, CThe anesthetic agent propofol (2,6-diisopropylphenol) is the most widely used intravenously administered drug in general anesthesia. However, a viable online capability to monitor metabolized levels of propofol in patients does not currently exist. Here we show for the first time that optical spectroscopy has good potential to detect metabolized propofol from patients' exhaled breath. We present quantitative absorption measurements of gas phase propofol both in the ultraviolet and middle-infrared spectral regions. We demonstrate that a detection limit in the subparts-per-billion concentration range can be reached with photoacoustic spectroscopy in the UV spectral region, paving the way for the development of future optical monitors. |
| spellingShingle | Laurila, T Sorvajärvi, T Saarela, J Toivonen, J Wheeler, D Ciaffoni, L Ritchie, G Kaminski, C Optical detection of the anesthetic agent propofol in the gas phase. |
| title | Optical detection of the anesthetic agent propofol in the gas phase. |
| title_full | Optical detection of the anesthetic agent propofol in the gas phase. |
| title_fullStr | Optical detection of the anesthetic agent propofol in the gas phase. |
| title_full_unstemmed | Optical detection of the anesthetic agent propofol in the gas phase. |
| title_short | Optical detection of the anesthetic agent propofol in the gas phase. |
| title_sort | optical detection of the anesthetic agent propofol in the gas phase |
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