The fabrication and characterization of bioengineered ultra-high molecular weight polyethylene-collagen-hap hybrid bone-cartilage patch
A layered hybrid implant was designed and fabricated for the surgical replacement of worn cartilage to meet the complex requirements of biocompatibility and mechanics. The natural hierarchical structure was purposefully mimicked to improve the implant performance and integration. The hybrid was fabr...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2020
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| _version_ | 1797095802190954496 |
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| author | Kan, Y Cvjetinovic, J Statnik, ES Ryazantsev, SV Anisimova, NY Kiselevskiy, MV Salimon, AI Maksimkin, AV Korsunsky, AM |
| author_facet | Kan, Y Cvjetinovic, J Statnik, ES Ryazantsev, SV Anisimova, NY Kiselevskiy, MV Salimon, AI Maksimkin, AV Korsunsky, AM |
| author_sort | Kan, Y |
| collection | OXFORD |
| description | A layered hybrid implant was designed and fabricated for the surgical replacement of worn cartilage to meet the complex requirements of biocompatibility and mechanics. The natural hierarchical structure was purposefully mimicked to improve the implant performance and integration. The hybrid was fabricated using three components: processed collagen gel, hydroxyapatite (HAp) powder and ultra-high molecular weight polyethylene (UHMWPE) in bulk and sponge form. The fabrication included hot molding, sacrificial templating, infusion, and freeze-casting stages. The hybrid had a porous transition layer made of porous UHMWPE impregnated with collagen by means of infusion. SEM and FTIR analyses confirmed successful collagen impregnation of porous UHMWPE. The morphology of transition layer was selected and produced to provide the UHMWPE pore size distribution in a range ∼50–150 μm that is favorable for the osseointegration by osteoblast proliferation. Biocompatibility tests were carried out in vitro. The index of red blood cells hemolysis showed 0.6 % after 4 h of co-incubation that proved excellent biocompatibility of the fabricated UHMWPE-Collagen-HAp hybrid. |
| first_indexed | 2024-03-07T04:33:08Z |
| format | Journal article |
| id | oxford-uuid:cf009c5a-dcbc-4a3e-8ce0-1a450774fd99 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:33:08Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:cf009c5a-dcbc-4a3e-8ce0-1a450774fd992022-03-27T07:39:32ZThe fabrication and characterization of bioengineered ultra-high molecular weight polyethylene-collagen-hap hybrid bone-cartilage patchJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cf009c5a-dcbc-4a3e-8ce0-1a450774fd99EnglishSymplectic ElementsElsevier2020Kan, YCvjetinovic, JStatnik, ESRyazantsev, SVAnisimova, NYKiselevskiy, MVSalimon, AIMaksimkin, AVKorsunsky, AMA layered hybrid implant was designed and fabricated for the surgical replacement of worn cartilage to meet the complex requirements of biocompatibility and mechanics. The natural hierarchical structure was purposefully mimicked to improve the implant performance and integration. The hybrid was fabricated using three components: processed collagen gel, hydroxyapatite (HAp) powder and ultra-high molecular weight polyethylene (UHMWPE) in bulk and sponge form. The fabrication included hot molding, sacrificial templating, infusion, and freeze-casting stages. The hybrid had a porous transition layer made of porous UHMWPE impregnated with collagen by means of infusion. SEM and FTIR analyses confirmed successful collagen impregnation of porous UHMWPE. The morphology of transition layer was selected and produced to provide the UHMWPE pore size distribution in a range ∼50–150 μm that is favorable for the osseointegration by osteoblast proliferation. Biocompatibility tests were carried out in vitro. The index of red blood cells hemolysis showed 0.6 % after 4 h of co-incubation that proved excellent biocompatibility of the fabricated UHMWPE-Collagen-HAp hybrid. |
| spellingShingle | Kan, Y Cvjetinovic, J Statnik, ES Ryazantsev, SV Anisimova, NY Kiselevskiy, MV Salimon, AI Maksimkin, AV Korsunsky, AM The fabrication and characterization of bioengineered ultra-high molecular weight polyethylene-collagen-hap hybrid bone-cartilage patch |
| title | The fabrication and characterization of bioengineered ultra-high molecular weight polyethylene-collagen-hap hybrid bone-cartilage patch |
| title_full | The fabrication and characterization of bioengineered ultra-high molecular weight polyethylene-collagen-hap hybrid bone-cartilage patch |
| title_fullStr | The fabrication and characterization of bioengineered ultra-high molecular weight polyethylene-collagen-hap hybrid bone-cartilage patch |
| title_full_unstemmed | The fabrication and characterization of bioengineered ultra-high molecular weight polyethylene-collagen-hap hybrid bone-cartilage patch |
| title_short | The fabrication and characterization of bioengineered ultra-high molecular weight polyethylene-collagen-hap hybrid bone-cartilage patch |
| title_sort | fabrication and characterization of bioengineered ultra high molecular weight polyethylene collagen hap hybrid bone cartilage patch |
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