HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: Analysis of a Nairobi-Kenyan cohort
In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection progression markers (i.e. CD4 cell counts and viral loads) and their assoc...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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| _version_ | 1797095820214927360 |
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| author | Abidi, S Shahid, A Lakhani, L Shah, R Okinda, N Ojwang, P Abbas, F Rowland-Jones, S Ali, S |
| author_facet | Abidi, S Shahid, A Lakhani, L Shah, R Okinda, N Ojwang, P Abbas, F Rowland-Jones, S Ali, S |
| author_sort | Abidi, S |
| collection | OXFORD |
| description | In a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection progression markers (i.e. CD4 cell counts and viral loads) and their association with HIV-1 genetic variability and subtype, and patient's HLA type. HIV-1 gag genetic variability, analysed using bioinformatics tools, showed an inverse relationship with CD4 cell count whereas with viral load that relationship was direct. Certain HLA types and viral subtypes were also found to associate with patients' viral load. Associations between disease parameters and the genetic makeup of the host and virus may be crucial in determining the outcome of HIV-1 infection. © 2013 Springer-Verlag Berlin Heidelberg. |
| first_indexed | 2024-03-07T04:33:24Z |
| format | Journal article |
| id | oxford-uuid:cf192408-b38e-45ed-968a-9526366941d3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:33:24Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:cf192408-b38e-45ed-968a-9526366941d32022-03-27T07:40:06ZHIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: Analysis of a Nairobi-Kenyan cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cf192408-b38e-45ed-968a-9526366941d3EnglishSymplectic Elements at Oxford2014Abidi, SShahid, ALakhani, LShah, ROkinda, NOjwang, PAbbas, FRowland-Jones, SAli, SIn a Nairobi-Kenyan cohort of 50 HIV-1 positive patients, we analysed the prevalence of HIV-1 subtypes and human leucocyte antigen (HLA) alleles. From this cohort, 33 patients were selected for the analysis of HIV-1 infection progression markers (i.e. CD4 cell counts and viral loads) and their association with HIV-1 genetic variability and subtype, and patient's HLA type. HIV-1 gag genetic variability, analysed using bioinformatics tools, showed an inverse relationship with CD4 cell count whereas with viral load that relationship was direct. Certain HLA types and viral subtypes were also found to associate with patients' viral load. Associations between disease parameters and the genetic makeup of the host and virus may be crucial in determining the outcome of HIV-1 infection. © 2013 Springer-Verlag Berlin Heidelberg. |
| spellingShingle | Abidi, S Shahid, A Lakhani, L Shah, R Okinda, N Ojwang, P Abbas, F Rowland-Jones, S Ali, S HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: Analysis of a Nairobi-Kenyan cohort |
| title | HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: Analysis of a Nairobi-Kenyan cohort |
| title_full | HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: Analysis of a Nairobi-Kenyan cohort |
| title_fullStr | HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: Analysis of a Nairobi-Kenyan cohort |
| title_full_unstemmed | HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: Analysis of a Nairobi-Kenyan cohort |
| title_short | HIV-1 progression links with viral genetic variability and subtype, and patient's HLA type: Analysis of a Nairobi-Kenyan cohort |
| title_sort | hiv 1 progression links with viral genetic variability and subtype and patient s hla type analysis of a nairobi kenyan cohort |
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