FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

Studies on hypoxia-sensitive pathways have identified a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. The asparaginyl hydroxylase factor inhibiting HIF (FIH) targets a conserved asparaginyl residue in the C-terminal tran...

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Dettagli Bibliografici
Autori principali:	Cockman, M, Webb, J, Ratcliffe, P
Natura:	Journal article
Lingua:	English
Pubblicazione:	2009

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