FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

Studies on hypoxia-sensitive pathways have identified a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. The asparaginyl hydroxylase factor inhibiting HIF (FIH) targets a conserved asparaginyl residue in the C-terminal tran...

書誌詳細
主要な著者:	Cockman, M, Webb, J, Ratcliffe, P
フォーマット:	Journal article
言語:	English
出版事項:	2009

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