FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.
Studies on hypoxia-sensitive pathways have identified a series of Fe(II)-dependent dioxygenases that regulate hypoxia-inducible factor (HIF) by prolyl and asparaginyl hydroxylation. The asparaginyl hydroxylase factor inhibiting HIF (FIH) targets a conserved asparaginyl residue in the C-terminal tran...
Những tác giả chính: | , , |
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Định dạng: | Journal article |
Ngôn ngữ: | English |
Được phát hành: |
2009
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