The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval.
Damage to the magnocellular mediodorsal thalamic nucleus (MDmc) in the human brain is associated with both retrograde and anterograde amnesia. In the present study we made selective neurotoxic MDmc lesions in rhesus monkeys and compared the effects of these lesions on memory acquisition and retrieva...
| Egile Nagusiak: | , |
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| Formatua: | Journal article |
| Hizkuntza: | English |
| Argitaratua: |
2008
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| _version_ | 1826297564361654272 |
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| author | Mitchell, A Gaffan, D |
| author_facet | Mitchell, A Gaffan, D |
| author_sort | Mitchell, A |
| collection | OXFORD |
| description | Damage to the magnocellular mediodorsal thalamic nucleus (MDmc) in the human brain is associated with both retrograde and anterograde amnesia. In the present study we made selective neurotoxic MDmc lesions in rhesus monkeys and compared the effects of these lesions on memory acquisition and retrieval. Monkeys learned 300 unique scene discriminations preoperatively and retention was assessed in a one-trial preoperative retrieval test. Bilateral neurotoxic lesions of the MDmc, produced by 10 x 1 microl injections of a mixture of ibotenate and NMDA did not affect performance in the postoperative one-trial retrieval test. In contrast, new postoperative learning of a further 100 novel scene discriminations was substantially impaired. Thus, MDmc is required for new learning of scene discriminations but not for their retention and retrieval. This finding is the first evidence that MDmc plays a specific role in memory acquisition. |
| first_indexed | 2024-03-07T04:33:34Z |
| format | Journal article |
| id | oxford-uuid:cf255f9c-0a95-413c-9b97-15c1a2d0c9ce |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:33:34Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:cf255f9c-0a95-413c-9b97-15c1a2d0c9ce2022-03-27T07:40:35ZThe magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cf255f9c-0a95-413c-9b97-15c1a2d0c9ceEnglishSymplectic Elements at Oxford2008Mitchell, AGaffan, DDamage to the magnocellular mediodorsal thalamic nucleus (MDmc) in the human brain is associated with both retrograde and anterograde amnesia. In the present study we made selective neurotoxic MDmc lesions in rhesus monkeys and compared the effects of these lesions on memory acquisition and retrieval. Monkeys learned 300 unique scene discriminations preoperatively and retention was assessed in a one-trial preoperative retrieval test. Bilateral neurotoxic lesions of the MDmc, produced by 10 x 1 microl injections of a mixture of ibotenate and NMDA did not affect performance in the postoperative one-trial retrieval test. In contrast, new postoperative learning of a further 100 novel scene discriminations was substantially impaired. Thus, MDmc is required for new learning of scene discriminations but not for their retention and retrieval. This finding is the first evidence that MDmc plays a specific role in memory acquisition. |
| spellingShingle | Mitchell, A Gaffan, D The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval. |
| title | The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval. |
| title_full | The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval. |
| title_fullStr | The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval. |
| title_full_unstemmed | The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval. |
| title_short | The magnocellular mediodorsal thalamus is necessary for memory acquisition, but not retrieval. |
| title_sort | magnocellular mediodorsal thalamus is necessary for memory acquisition but not retrieval |
| work_keys_str_mv | AT mitchella themagnocellularmediodorsalthalamusisnecessaryformemoryacquisitionbutnotretrieval AT gaffand themagnocellularmediodorsalthalamusisnecessaryformemoryacquisitionbutnotretrieval AT mitchella magnocellularmediodorsalthalamusisnecessaryformemoryacquisitionbutnotretrieval AT gaffand magnocellularmediodorsalthalamusisnecessaryformemoryacquisitionbutnotretrieval |