Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms.
<h4>Background</h4> <p>PWhether neuronal nitric-oxide synthase (nNOS) plays a role in the endothelial NOS (eNOS)-dependent negative inotropic effect of β3-adrenergic stimulation remains to be established.</p> <h4>Results</h4> <p>nNOS knock-out or inhibition...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Society of Biochemistry and Molecular Biology
2012
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| _version_ | 1826297565584293888 |
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| author | Idigo, W Reilly, S Zhang, M Zhang, Y Jayaram, R Carnicer, R Crabtree, M Balligand, J Casadei, B |
| author_facet | Idigo, W Reilly, S Zhang, M Zhang, Y Jayaram, R Carnicer, R Crabtree, M Balligand, J Casadei, B |
| author_sort | Idigo, W |
| collection | OXFORD |
| description | <h4>Background</h4> <p>PWhether neuronal nitric-oxide synthase (nNOS) plays a role in the endothelial NOS (eNOS)-dependent negative inotropic effect of β3-adrenergic stimulation remains to be established.</p> <h4>Results</h4> <p>nNOS knock-out or inhibition leads to increased superoxide production, eNOS uncoupling, and abrogation of β3-adrenergic responses.</p> <h4>Conclusion</h4> <p>Disabling nNOS disrupts eNOS function and downstream signaling.</p> <h4>Significance</h4> <p>nNOS plays a crucial role in preserving myocardial nitroso-redox balance and coupled eNOS activity.</p> |
| first_indexed | 2024-03-07T04:33:35Z |
| format | Journal article |
| id | oxford-uuid:cf26ec82-a4cd-4196-b108-a4ff72044147 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:33:35Z |
| publishDate | 2012 |
| publisher | American Society of Biochemistry and Molecular Biology |
| record_format | dspace |
| spelling | oxford-uuid:cf26ec82-a4cd-4196-b108-a4ff720441472022-03-27T07:40:40ZRegulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cf26ec82-a4cd-4196-b108-a4ff72044147EnglishSymplectic Elements at OxfordAmerican Society of Biochemistry and Molecular Biology2012Idigo, WReilly, SZhang, MZhang, YJayaram, RCarnicer, RCrabtree, MBalligand, JCasadei, B <h4>Background</h4> <p>PWhether neuronal nitric-oxide synthase (nNOS) plays a role in the endothelial NOS (eNOS)-dependent negative inotropic effect of β3-adrenergic stimulation remains to be established.</p> <h4>Results</h4> <p>nNOS knock-out or inhibition leads to increased superoxide production, eNOS uncoupling, and abrogation of β3-adrenergic responses.</p> <h4>Conclusion</h4> <p>Disabling nNOS disrupts eNOS function and downstream signaling.</p> <h4>Significance</h4> <p>nNOS plays a crucial role in preserving myocardial nitroso-redox balance and coupled eNOS activity.</p> |
| spellingShingle | Idigo, W Reilly, S Zhang, M Zhang, Y Jayaram, R Carnicer, R Crabtree, M Balligand, J Casadei, B Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms. |
| title | Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms. |
| title_full | Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms. |
| title_fullStr | Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms. |
| title_full_unstemmed | Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms. |
| title_short | Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms. |
| title_sort | regulation of endothelial nitric oxide synthase nos s glutathionylation by neuronal nos evidence of a functional interaction between myocardial constitutive nos isoforms |
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