1,25-dihydroxycholecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism.

1,25-dihydroxycholecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism.

Small amounts (0·68-2·7 μg.) of 1,25- dihydroxycholecalciferol (1,25-D.H.C.C.), the hormonally active metabolite of vitamin D3, or its synthetic analogue 1α-hydroxycholecalciferol (1α-H.C.C.) rapidly corrected the low plasma-calcium and improved symptoms when given daily to two patients with hypopar...

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Detalles Bibliográficos
Main Authors: Russell, R, Smith, R, Walton, R, Preston, C, Basson, R, Henderson, R, Norman, A
Formato: Journal article
Idioma:English
Publicado: 1974
Descripción
Summary:Small amounts (0·68-2·7 μg.) of 1,25- dihydroxycholecalciferol (1,25-D.H.C.C.), the hormonally active metabolite of vitamin D3, or its synthetic analogue 1α-hydroxycholecalciferol (1α-H.C.C.) rapidly corrected the low plasma-calcium and improved symptoms when given daily to two patients with hypoparathyroidism. The rise in plasma-calcium could be maintained for as long as treatment continued but was readily reversible. The efficacy of minute doses of 1,25-D.H.C.C. and 1α-H.C.C. may indicate that the production of biologically active metabolites of vitamin D is impaired in hypoparathyroidism, and could offer advantages in treatment. © 1974.

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