1,25-dihydroxycholecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism.
Small amounts (0·68-2·7 μg.) of 1,25- dihydroxycholecalciferol (1,25-D.H.C.C.), the hormonally active metabolite of vitamin D3, or its synthetic analogue 1α-hydroxycholecalciferol (1α-H.C.C.) rapidly corrected the low plasma-calcium and improved symptoms when given daily to two patients with hypopar...
| Автори: | , , , , , , |
|---|---|
| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
1974
|
| _version_ | 1826297572714610688 |
|---|---|
| author | Russell, R Smith, R Walton, R Preston, C Basson, R Henderson, R Norman, A |
| author_facet | Russell, R Smith, R Walton, R Preston, C Basson, R Henderson, R Norman, A |
| author_sort | Russell, R |
| collection | OXFORD |
| description | Small amounts (0·68-2·7 μg.) of 1,25- dihydroxycholecalciferol (1,25-D.H.C.C.), the hormonally active metabolite of vitamin D3, or its synthetic analogue 1α-hydroxycholecalciferol (1α-H.C.C.) rapidly corrected the low plasma-calcium and improved symptoms when given daily to two patients with hypoparathyroidism. The rise in plasma-calcium could be maintained for as long as treatment continued but was readily reversible. The efficacy of minute doses of 1,25-D.H.C.C. and 1α-H.C.C. may indicate that the production of biologically active metabolites of vitamin D is impaired in hypoparathyroidism, and could offer advantages in treatment. © 1974. |
| first_indexed | 2024-03-07T04:33:42Z |
| format | Journal article |
| id | oxford-uuid:cf32b6d7-9af3-401c-9058-c9f60715deca |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:33:42Z |
| publishDate | 1974 |
| record_format | dspace |
| spelling | oxford-uuid:cf32b6d7-9af3-401c-9058-c9f60715deca2022-03-27T07:40:56Z1,25-dihydroxycholecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cf32b6d7-9af3-401c-9058-c9f60715decaEnglishSymplectic Elements at Oxford1974Russell, RSmith, RWalton, RPreston, CBasson, RHenderson, RNorman, ASmall amounts (0·68-2·7 μg.) of 1,25- dihydroxycholecalciferol (1,25-D.H.C.C.), the hormonally active metabolite of vitamin D3, or its synthetic analogue 1α-hydroxycholecalciferol (1α-H.C.C.) rapidly corrected the low plasma-calcium and improved symptoms when given daily to two patients with hypoparathyroidism. The rise in plasma-calcium could be maintained for as long as treatment continued but was readily reversible. The efficacy of minute doses of 1,25-D.H.C.C. and 1α-H.C.C. may indicate that the production of biologically active metabolites of vitamin D is impaired in hypoparathyroidism, and could offer advantages in treatment. © 1974. |
| spellingShingle | Russell, R Smith, R Walton, R Preston, C Basson, R Henderson, R Norman, A 1,25-dihydroxycholecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism. |
| title | 1,25-dihydroxycholecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism. |
| title_full | 1,25-dihydroxycholecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism. |
| title_fullStr | 1,25-dihydroxycholecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism. |
| title_full_unstemmed | 1,25-dihydroxycholecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism. |
| title_short | 1,25-dihydroxycholecalciferol and 1alpha-hydroxycholecalciferol in hypoparathyroidism. |
| title_sort | 1 25 dihydroxycholecalciferol and 1alpha hydroxycholecalciferol in hypoparathyroidism |
| work_keys_str_mv | AT russellr 125dihydroxycholecalciferoland1alphahydroxycholecalciferolinhypoparathyroidism AT smithr 125dihydroxycholecalciferoland1alphahydroxycholecalciferolinhypoparathyroidism AT waltonr 125dihydroxycholecalciferoland1alphahydroxycholecalciferolinhypoparathyroidism AT prestonc 125dihydroxycholecalciferoland1alphahydroxycholecalciferolinhypoparathyroidism AT bassonr 125dihydroxycholecalciferoland1alphahydroxycholecalciferolinhypoparathyroidism AT hendersonr 125dihydroxycholecalciferoland1alphahydroxycholecalciferolinhypoparathyroidism AT normana 125dihydroxycholecalciferoland1alphahydroxycholecalciferolinhypoparathyroidism |