Left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content.
OBJECTIVE: Neuro-imaging studies have suggested that the ability to imitate meaningless and meaningful gestures may differentially depend on superior (SPL) and inferior (IPL) parietal lobule. Therefore, we hypothesized that imaging-guided neuro-navigated continuous theta burst stimulation (cTBS) ove...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2014
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| _version_ | 1826297576646770688 |
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| author | Vanbellingen, T Bertschi, M Nyffeler, T Cazzoli, D Wiest, R Bassetti, C Kaelin-Lang, A Müri, R Bohlhalter, S |
| author_facet | Vanbellingen, T Bertschi, M Nyffeler, T Cazzoli, D Wiest, R Bassetti, C Kaelin-Lang, A Müri, R Bohlhalter, S |
| author_sort | Vanbellingen, T |
| collection | OXFORD |
| description | OBJECTIVE: Neuro-imaging studies have suggested that the ability to imitate meaningless and meaningful gestures may differentially depend on superior (SPL) and inferior (IPL) parietal lobule. Therefore, we hypothesized that imaging-guided neuro-navigated continuous theta burst stimulation (cTBS) over left SPL mainly affects meaningless and over left IPL predominantly meaningful gestures. METHODS: Twelve healthy subjects participated in this study. High resolution structural MRI was used for imaging guided neuro-navigation cTBS. Participants were targeted with one train of cTBS in three experimental sessions: sham stimulation over vertex and real cTBS over left SPL and IPL, respectively. An imitation task, including 24 meaningless and 24 meaningful gestures, was performed 'offline'. RESULTS: cTBS over both left IPL and SPL significantly interfered with gestural imitation. There was no differential effect of SPL and IPL cTBS on gesture type (meaningless versus meaningful). CONCLUSIONS: Our findings confirm that left posterior parietal cortex plays a predominant role in gestural imitation. However, the hypothesis based on the dual route model suggesting a differential role of SPL and IPL in the processing of meaningless and meaningful gestures could not be confirmed. SIGNIFICANCE: Left SPL and IPL play a common role within the posterior-parietal network in gestural imitation regardless of semantic content. |
| first_indexed | 2024-03-07T04:33:45Z |
| format | Journal article |
| id | oxford-uuid:cf37f23d-9d8e-42f1-8eee-cf38de4e2149 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:33:45Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:cf37f23d-9d8e-42f1-8eee-cf38de4e21492022-03-27T07:40:58ZLeft posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cf37f23d-9d8e-42f1-8eee-cf38de4e2149EnglishSymplectic Elements at Oxford2014Vanbellingen, TBertschi, MNyffeler, TCazzoli, DWiest, RBassetti, CKaelin-Lang, AMüri, RBohlhalter, SOBJECTIVE: Neuro-imaging studies have suggested that the ability to imitate meaningless and meaningful gestures may differentially depend on superior (SPL) and inferior (IPL) parietal lobule. Therefore, we hypothesized that imaging-guided neuro-navigated continuous theta burst stimulation (cTBS) over left SPL mainly affects meaningless and over left IPL predominantly meaningful gestures. METHODS: Twelve healthy subjects participated in this study. High resolution structural MRI was used for imaging guided neuro-navigation cTBS. Participants were targeted with one train of cTBS in three experimental sessions: sham stimulation over vertex and real cTBS over left SPL and IPL, respectively. An imitation task, including 24 meaningless and 24 meaningful gestures, was performed 'offline'. RESULTS: cTBS over both left IPL and SPL significantly interfered with gestural imitation. There was no differential effect of SPL and IPL cTBS on gesture type (meaningless versus meaningful). CONCLUSIONS: Our findings confirm that left posterior parietal cortex plays a predominant role in gestural imitation. However, the hypothesis based on the dual route model suggesting a differential role of SPL and IPL in the processing of meaningless and meaningful gestures could not be confirmed. SIGNIFICANCE: Left SPL and IPL play a common role within the posterior-parietal network in gestural imitation regardless of semantic content. |
| spellingShingle | Vanbellingen, T Bertschi, M Nyffeler, T Cazzoli, D Wiest, R Bassetti, C Kaelin-Lang, A Müri, R Bohlhalter, S Left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content. |
| title | Left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content. |
| title_full | Left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content. |
| title_fullStr | Left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content. |
| title_full_unstemmed | Left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content. |
| title_short | Left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content. |
| title_sort | left posterior parietal theta burst stimulation affects gestural imitation regardless of semantic content |
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