Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2

Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2

Prolyl hydroxylase (PHD) enzymes play a critical role in the cellular responses to hypoxia through their regulation of the hypoxia inducible factor α (HIF-α) transcription factors. PHD inhibitors show promise for the treatment of diseases including anaemia, cardiovascular disease and stroke. In this...

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Dettagli Bibliografici
Autori principali:	Richardson, NL, O'Malley, LJ, Weissberger, D, Tumber, A, Schofield, CJ, Griffith, R, Jones, NM, Hunter, L
Natura:	Journal article
Lingua:	English
Pubblicazione:	Elsevier 2021

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