Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain
Objective: Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system associated with pathogenic autoantibodies against the astrocyte water channel protein aquaporin-4 (AQP4). The presence of neutrophils is a characteristic feature in NMO lesions in humans. Neu...
Egile Nagusiak: | Saadoun, S, Waters, P, MacDonald, C, Bell, B, Vincent, A, Verkman, A, Papadopoulos, M |
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Formatua: | Journal article |
Hizkuntza: | English |
Argitaratua: |
2012
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Antzeko izenburuak
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Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain.
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Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice.
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Neutrophil protease inhibition reduces NMO-IgG-induced damage in mouse brain
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Effect of IgG from seronegative and seropositive neuromyelitis optica patients on mouse brain
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Neuromyelitis optica IgG causes placental inflammation and fetal death.
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