The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.
Two stable analogues of enkephalin D-Ala2-Met5-enkephalinamide (DAMA) and D-Ala2,D-Leu5-enkephalin (DADLE) injected bilaterally into the ventral tegmental area (VTA) induced locomotion, characterized by bursts of morphine-like activity. The response of DADLE was blocked by systemic-alpha-flupenthixo...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1981
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| _version_ | 1826297619546112000 |
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| author | Joyce, E Koob, G Strecker, R Iversen, S Bloom, F |
| author_facet | Joyce, E Koob, G Strecker, R Iversen, S Bloom, F |
| author_sort | Joyce, E |
| collection | OXFORD |
| description | Two stable analogues of enkephalin D-Ala2-Met5-enkephalinamide (DAMA) and D-Ala2,D-Leu5-enkephalin (DADLE) injected bilaterally into the ventral tegmental area (VTA) induced locomotion, characterized by bursts of morphine-like activity. The response of DADLE was blocked by systemic-alpha-flupenthixol (0.2 mg/kg) and naloxone (1 mg/kg). At higher doses of enkephalins in the VTA, stereotypy behaviour involving gnawing, became apparent. When injected bilaterally into the globus pallidus (GP), both analogues induced a dose-dependent increase in locomotor activity but stereotypy was not observed. The locomotor behaviour induced by DADLE was blocked by naloxone but not by alpha-flupenthixol. These results suggest that naloxone-sensitive opiate receptors modulate, at a number of different sites, the neural pathways involved in the expression of behavioural activity. |
| first_indexed | 2024-03-07T04:34:25Z |
| format | Journal article |
| id | oxford-uuid:cf7359d4-f436-48f0-888d-935c57a3e3a7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:34:25Z |
| publishDate | 1981 |
| record_format | dspace |
| spelling | oxford-uuid:cf7359d4-f436-48f0-888d-935c57a3e3a72022-03-27T07:42:28ZThe behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cf7359d4-f436-48f0-888d-935c57a3e3a7EnglishSymplectic Elements at Oxford1981Joyce, EKoob, GStrecker, RIversen, SBloom, FTwo stable analogues of enkephalin D-Ala2-Met5-enkephalinamide (DAMA) and D-Ala2,D-Leu5-enkephalin (DADLE) injected bilaterally into the ventral tegmental area (VTA) induced locomotion, characterized by bursts of morphine-like activity. The response of DADLE was blocked by systemic-alpha-flupenthixol (0.2 mg/kg) and naloxone (1 mg/kg). At higher doses of enkephalins in the VTA, stereotypy behaviour involving gnawing, became apparent. When injected bilaterally into the globus pallidus (GP), both analogues induced a dose-dependent increase in locomotor activity but stereotypy was not observed. The locomotor behaviour induced by DADLE was blocked by naloxone but not by alpha-flupenthixol. These results suggest that naloxone-sensitive opiate receptors modulate, at a number of different sites, the neural pathways involved in the expression of behavioural activity. |
| spellingShingle | Joyce, E Koob, G Strecker, R Iversen, S Bloom, F The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus. |
| title | The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus. |
| title_full | The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus. |
| title_fullStr | The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus. |
| title_full_unstemmed | The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus. |
| title_short | The behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus. |
| title_sort | behavioural effects of enkephalin analogues injected into the ventral tegmental area and globus pallidus |
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