Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease

Genetic association studies have identified 215 risk loci for inflammatory bowel disease, thereby uncovering fundamental aspects of its molecular biology. We performed a genome-wide association study of 25,305 individuals and conducted a meta-analysis with published summary statistics, yielding a to...

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Opis bibliograficzny
Główni autorzy: de Lange, K, Moutsianas, L, Lee, J, Lamb, C, Luo, Y, Kennedy, N, Jostins, L, Rice, D, Gutierrez-Achury, J, Ji, S, Heap, G, Nimmo, E, Edwards, C, Henderson, P, Mowat, C, Sanderson, J, Satsangi, J, Simmons, A, Wilson, D, Tremelling, M, Hart, A, Mathew, C, Newman, W, Parkes, M, Lees, C, Uhlig, H, Hawkey, C, Prescott, N, Ahmad, T, Mansfield, J, Anderson, C, Barrett, J
Format: Journal article
Wydane: Nature Publishing Group 2017