Accurate Prediction of Ligand Affinities for a Proton-Dependent Oligopeptide Transporter
Membrane transporters are critical modulators of drug pharmacokinetics, efficacy, and safety. One example is the proton-dependent oligopeptide transporter PepT1, also known as SLC15A1, which is responsible for the uptake of the β-lactam antibiotics and various peptide-based prodrugs. In this study,...
| Main Authors: | , , , , |
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| Formato: | Journal article |
| Publicado em: |
Cell Press
2016
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