The root growth-regulating brevicompanine natural products modulate the plant circadian clock
Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompa...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Chemical Society
2017
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| _version_ | 1826297653949890560 |
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| author | De Montaigu, A Oeljeklaus, J Krahn, J Suliman, M Halder, V De Ansorena, E Nickel, S Schlicht, M Plíhal, O Kubiasová, K Radová, L Kracher, B Tóth, R Kaschani, F Coupland, G Kombrink, E Kaiser, M |
| author_facet | De Montaigu, A Oeljeklaus, J Krahn, J Suliman, M Halder, V De Ansorena, E Nickel, S Schlicht, M Plíhal, O Kubiasová, K Radová, L Kracher, B Tóth, R Kaschani, F Coupland, G Kombrink, E Kaiser, M |
| author_sort | De Montaigu, A |
| collection | OXFORD |
| description | Plant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. These studies demonstrated that brevicompanines cause transcriptional misregulation of core components of the circadian clock, whereas other biological read-outs were not affected. Brevicompanines thus represent promising chemical tools for investigating the regulation of the plant circadian clock. In addition, our study also illustrates the potential of an unbiased -omics-based characterization of bioactive compounds for identifying the often cryptic modes of action of small molecules. |
| first_indexed | 2024-03-07T04:34:59Z |
| format | Journal article |
| id | oxford-uuid:cf9b2c40-9227-4a4f-bc1e-bf26cb4a9584 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:34:59Z |
| publishDate | 2017 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:cf9b2c40-9227-4a4f-bc1e-bf26cb4a95842022-03-27T07:44:00ZThe root growth-regulating brevicompanine natural products modulate the plant circadian clockJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cf9b2c40-9227-4a4f-bc1e-bf26cb4a9584EnglishSymplectic Elements at OxfordAmerican Chemical Society2017De Montaigu, AOeljeklaus, JKrahn, JSuliman, MHalder, VDe Ansorena, ENickel, SSchlicht, MPlíhal, OKubiasová, KRadová, LKracher, BTóth, RKaschani, FCoupland, GKombrink, EKaiser, MPlant growth regulating properties of brevicompanines (Brvs), natural products of the fungus Penicillium brevicompactum, have been known for several years, but further investigations into the molecular mechanism of their bioactivity have not been performed. Following chemical synthesis of brevicompanine derivatives, we studied their activity in the model plant Arabidopsis by a combination of plant growth assays, transcriptional profiling, and numerous additional bioassays. These studies demonstrated that brevicompanines cause transcriptional misregulation of core components of the circadian clock, whereas other biological read-outs were not affected. Brevicompanines thus represent promising chemical tools for investigating the regulation of the plant circadian clock. In addition, our study also illustrates the potential of an unbiased -omics-based characterization of bioactive compounds for identifying the often cryptic modes of action of small molecules. |
| spellingShingle | De Montaigu, A Oeljeklaus, J Krahn, J Suliman, M Halder, V De Ansorena, E Nickel, S Schlicht, M Plíhal, O Kubiasová, K Radová, L Kracher, B Tóth, R Kaschani, F Coupland, G Kombrink, E Kaiser, M The root growth-regulating brevicompanine natural products modulate the plant circadian clock |
| title | The root growth-regulating brevicompanine natural products modulate the plant circadian clock |
| title_full | The root growth-regulating brevicompanine natural products modulate the plant circadian clock |
| title_fullStr | The root growth-regulating brevicompanine natural products modulate the plant circadian clock |
| title_full_unstemmed | The root growth-regulating brevicompanine natural products modulate the plant circadian clock |
| title_short | The root growth-regulating brevicompanine natural products modulate the plant circadian clock |
| title_sort | root growth regulating brevicompanine natural products modulate the plant circadian clock |
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