Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions

A person’s lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipo...

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Hlavní autoři:	de Vries, PS, Watkins, H, Brown, MR, Bentley, AR, Sung, YJ, Winkler, TW, Ntalla, I, Schwander, K, Kraja, AT, Guo, X, InterAct Consortium, Franceschini, N, Cheng, C-Y, Sim, X, Vojinovic, D, Huffman, JE, Musani, SK, Li, C, Feitosa, MF, Richard, MA, Noordam, R, Aschard, H, Bartz, TM, Bielak, LF, Deng, X, Dorajoo, R, Lohman, KK, Manning, AK, Rankinen, T, Smith, AV, Tajuddin, SM, Evangelou, E, Graff, M, Alver, M, Boissel, M, Chai, JF, Chen, X, Divers, J, Gandin, I, Gao, C, Goel, A, Hagemeijer, Y, Harris, SE, Hartwig, FP, He, M, Horimoto, ARVR, Hsu, F-C, Jackson, AU, Kasturiratne, A, Komulainen, P, Kühnel, B, Laguzzi, F, Lee, JH, Luan, J, Lyytikäinen, L-P, Matoba, N, Nolte, IM, Pietzner, M, Riaz, M, Said, MA, Scott, RA, Sofer, T, Stančáková, A, Takeuchi, F, Tayo, BO, van der Most, PJ, Varga, TV, Wang, Y, Ware, EB, Wen, W, Yanek, LR, Zhang, W, Zhao, JH, Afaq, S, Amin, N, Amini, M, Arking, DE, Aung, T, Ballantyne, C, Boerwinkle, E, Broeckel, U, Campbell, A, Canouil, M, Charumathi, S, Chen, Y-DI, Connell, JM, de Faire, U, de Las Fuentes, L, de Mutsert, R, de Silva, HJ, Ding, J, Dominiczak, AF, Duan, Q, Eaton, CB, Eppinga, RN, Faul, JD, Fisher, V, Forrester, T, Franco, OH, Friedlander, Y, Ghanbari, M, Giulianini, F, Grabe, HJ, Grove, ML, Gu, CC, Harris, TB, Heikkinen, S, Heng, C-K, Hirata, M, Hixson, JE, Howard, BV, Ikram, MA, Jacobs, DR, Johnson, C, Jonas, JB, Kammerer, CM, Katsuya, T, Khor, CC, Kilpeläinen, TO, Koh, W-P, Koistinen, HA, Kolcic, I, Kooperberg, C, Krieger, JE, Kritchevsky, SB, Kubo, M, Kuusisto, J, Lakka, TA, Langefeld, CD, Langenberg, C, Launer, LJ, Lehne, B, Lemaitre, RN, Li, Y, Liang, J, Liu, J, Liu, K, Loh, M, Louie, T, Mägi, R, Manichaikul, AW, McKenzie, CA, Meitinger, T, Metspalu, A, Milaneschi, Y, Milani, L, Mohlke, KL, Mosley, TH, Mukamal, KJ, Nalls, MA, Nauck, M, Nelson, CP, Sotoodehnia, N, O'Connell, JR, Palmer, ND, Pazoki, R, Pedersen, NL, Peters, A, Peyser, PA, Polasek, O, Poulter, N, Raffel, LJ, Raitakari, OT, Reiner, AP, Rice, TK, Rich, SS, Robino, A, Robinson, JG, Rose, LM, Rudan, I, Schmidt, CO, Schreiner, PJ, Scott, WR, Sever, P, Shi, Y, Sidney, S, Sims, M, Smith, BH, Smith, JA, Snieder, H, Starr, JM, Strauch, K, Tan, N, Taylor, KD, Teo, YY, Tham, YC, Uitterlinden, AG, van Heemst, D, Vuckovic, D, Waldenberger, M, Wang, L, Wang, Z, Wei, WB, Williams, C, Wilson, G, Wojczynski, MK, Yao, J, Yu, B, Yu, C, Yuan, J-M, Zhao, W, Zonderman, AB, Becker, DM, Boehnke, M, Bowden, DW, Chambers, JC, Deary, IJ, Esko, T, Farrall, M, Franks, PW, Freedman, BI, Froguel, P, Gasparini, P, Gieger, C, Horta, BL, Kamatani, Y, Kato, N, Kooner, JS, Laakso, M, Leander, K, Lehtimäki, T, Magnusson, PKE, Penninx, B, Pereira, AC, Rauramaa, R, Samani, NJ, Scott, J, Shu, X-O, van der Harst, P, Wagenknecht, LE, Wang, YX, Wareham, NJ, Weir, DR, Wickremasinghe, AR, Zheng, W, Elliott, P, North, KE, Bouchard, C, Evans, MK, Gudnason, V, Liu, C-T, Liu, Y, Psaty, BM, Ridker, PM, van Dam, RM, Kardia, SLR, Zhu, X, Rotimi, CN, Mook-Kanamori, DO, Fornage, M, Kelly, TN, Fox, ER, Hayward, C, van Duijn, CM, Tai, ES, Wong, TY, Rotter, JI, Gauderman, WJ, Province, MA, Munroe, PB, Rice, K, Chasman, DI, Cupples, LA, Rao, DC, Morrison, AC
Další autoři:	Lifelines Cohort, Groningen, The Netherlands (Lifelines Cohort Study)
Médium:	Journal article
Jazyk:	English
Vydáno:	Oxford University Press 2019

_version_	1826297663400706048
author	de Vries, PS Watkins, H Brown, MR Bentley, AR Sung, YJ Winkler, TW Ntalla, I Schwander, K Kraja, AT Guo, X InterAct Consortium Franceschini, N Cheng, C-Y Sim, X Vojinovic, D Huffman, JE Musani, SK Li, C Feitosa, MF Richard, MA Noordam, R Aschard, H Bartz, TM Bielak, LF Deng, X Dorajoo, R Lohman, KK Manning, AK Rankinen, T Smith, AV Tajuddin, SM Evangelou, E Graff, M Alver, M Boissel, M Chai, JF Chen, X Divers, J Gandin, I Gao, C Goel, A Hagemeijer, Y Harris, SE Hartwig, FP He, M Horimoto, ARVR Hsu, F-C Jackson, AU Kasturiratne, A Komulainen, P Kühnel, B Laguzzi, F Lee, JH Luan, J Lyytikäinen, L-P Matoba, N Nolte, IM Pietzner, M Riaz, M Said, MA Scott, RA Sofer, T Stančáková, A Takeuchi, F Tayo, BO van der Most, PJ Varga, TV Wang, Y Ware, EB Wen, W Yanek, LR Zhang, W Zhao, JH Afaq, S Amin, N Amini, M Arking, DE Aung, T Ballantyne, C Boerwinkle, E Broeckel, U Campbell, A Canouil, M Charumathi, S Chen, Y-DI Connell, JM de Faire, U de Las Fuentes, L de Mutsert, R de Silva, HJ Ding, J Dominiczak, AF Duan, Q Eaton, CB Eppinga, RN Faul, JD Fisher, V Forrester, T Franco, OH Friedlander, Y Ghanbari, M Giulianini, F Grabe, HJ Grove, ML Gu, CC Harris, TB Heikkinen, S Heng, C-K Hirata, M Hixson, JE Howard, BV Ikram, MA Jacobs, DR Johnson, C Jonas, JB Kammerer, CM Katsuya, T Khor, CC Kilpeläinen, TO Koh, W-P Koistinen, HA Kolcic, I Kooperberg, C Krieger, JE Kritchevsky, SB Kubo, M Kuusisto, J Lakka, TA Langefeld, CD Langenberg, C Launer, LJ Lehne, B Lemaitre, RN Li, Y Liang, J Liu, J Liu, K Loh, M Louie, T Mägi, R Manichaikul, AW McKenzie, CA Meitinger, T Metspalu, A Milaneschi, Y Milani, L Mohlke, KL Mosley, TH Mukamal, KJ Nalls, MA Nauck, M Nelson, CP Sotoodehnia, N O'Connell, JR Palmer, ND Pazoki, R Pedersen, NL Peters, A Peyser, PA Polasek, O Poulter, N Raffel, LJ Raitakari, OT Reiner, AP Rice, TK Rich, SS Robino, A Robinson, JG Rose, LM Rudan, I Schmidt, CO Schreiner, PJ Scott, WR Sever, P Shi, Y Sidney, S Sims, M Smith, BH Smith, JA Snieder, H Starr, JM Strauch, K Tan, N Taylor, KD Teo, YY Tham, YC Uitterlinden, AG van Heemst, D Vuckovic, D Waldenberger, M Wang, L Wang, Y Wang, Z Wei, WB Williams, C Wilson, G Wojczynski, MK Yao, J Yu, B Yu, C Yuan, J-M Zhao, W Zonderman, AB Becker, DM Boehnke, M Bowden, DW Chambers, JC Deary, IJ Esko, T Farrall, M Franks, PW Freedman, BI Froguel, P Gasparini, P Gieger, C Horta, BL Kamatani, Y Kato, N Kooner, JS Laakso, M Leander, K Lehtimäki, T Magnusson, PKE Penninx, B Pereira, AC Rauramaa, R Samani, NJ Scott, J Shu, X-O van der Harst, P Wagenknecht, LE Wang, YX Wareham, NJ Weir, DR Wickremasinghe, AR Zheng, W Elliott, P North, KE Bouchard, C Evans, MK Gudnason, V Liu, C-T Liu, Y Psaty, BM Ridker, PM van Dam, RM Kardia, SLR Zhu, X Rotimi, CN Mook-Kanamori, DO Fornage, M Kelly, TN Fox, ER Hayward, C van Duijn, CM Tai, ES Wong, TY Liu, J Rotter, JI Gauderman, WJ Province, MA Munroe, PB Rice, K Chasman, DI Cupples, LA Rao, DC Morrison, AC
author2	Lifelines Cohort, Groningen, The Netherlands (Lifelines Cohort Study),
author_facet	Lifelines Cohort, Groningen, The Netherlands (Lifelines Cohort Study), de Vries, PS Watkins, H Brown, MR Bentley, AR Sung, YJ Winkler, TW Ntalla, I Schwander, K Kraja, AT Guo, X InterAct Consortium Franceschini, N Cheng, C-Y Sim, X Vojinovic, D Huffman, JE Musani, SK Li, C Feitosa, MF Richard, MA Noordam, R Aschard, H Bartz, TM Bielak, LF Deng, X Dorajoo, R Lohman, KK Manning, AK Rankinen, T Smith, AV Tajuddin, SM Evangelou, E Graff, M Alver, M Boissel, M Chai, JF Chen, X Divers, J Gandin, I Gao, C Goel, A Hagemeijer, Y Harris, SE Hartwig, FP He, M Horimoto, ARVR Hsu, F-C Jackson, AU Kasturiratne, A Komulainen, P Kühnel, B Laguzzi, F Lee, JH Luan, J Lyytikäinen, L-P Matoba, N Nolte, IM Pietzner, M Riaz, M Said, MA Scott, RA Sofer, T Stančáková, A Takeuchi, F Tayo, BO van der Most, PJ Varga, TV Wang, Y Ware, EB Wen, W Yanek, LR Zhang, W Zhao, JH Afaq, S Amin, N Amini, M Arking, DE Aung, T Ballantyne, C Boerwinkle, E Broeckel, U Campbell, A Canouil, M Charumathi, S Chen, Y-DI Connell, JM de Faire, U de Las Fuentes, L de Mutsert, R de Silva, HJ Ding, J Dominiczak, AF Duan, Q Eaton, CB Eppinga, RN Faul, JD Fisher, V Forrester, T Franco, OH Friedlander, Y Ghanbari, M Giulianini, F Grabe, HJ Grove, ML Gu, CC Harris, TB Heikkinen, S Heng, C-K Hirata, M Hixson, JE Howard, BV Ikram, MA Jacobs, DR Johnson, C Jonas, JB Kammerer, CM Katsuya, T Khor, CC Kilpeläinen, TO Koh, W-P Koistinen, HA Kolcic, I Kooperberg, C Krieger, JE Kritchevsky, SB Kubo, M Kuusisto, J Lakka, TA Langefeld, CD Langenberg, C Launer, LJ Lehne, B Lemaitre, RN Li, Y Liang, J Liu, J Liu, K Loh, M Louie, T Mägi, R Manichaikul, AW McKenzie, CA Meitinger, T Metspalu, A Milaneschi, Y Milani, L Mohlke, KL Mosley, TH Mukamal, KJ Nalls, MA Nauck, M Nelson, CP Sotoodehnia, N O'Connell, JR Palmer, ND Pazoki, R Pedersen, NL Peters, A Peyser, PA Polasek, O Poulter, N Raffel, LJ Raitakari, OT Reiner, AP Rice, TK Rich, SS Robino, A Robinson, JG Rose, LM Rudan, I Schmidt, CO Schreiner, PJ Scott, WR Sever, P Shi, Y Sidney, S Sims, M Smith, BH Smith, JA Snieder, H Starr, JM Strauch, K Tan, N Taylor, KD Teo, YY Tham, YC Uitterlinden, AG van Heemst, D Vuckovic, D Waldenberger, M Wang, L Wang, Y Wang, Z Wei, WB Williams, C Wilson, G Wojczynski, MK Yao, J Yu, B Yu, C Yuan, J-M Zhao, W Zonderman, AB Becker, DM Boehnke, M Bowden, DW Chambers, JC Deary, IJ Esko, T Farrall, M Franks, PW Freedman, BI Froguel, P Gasparini, P Gieger, C Horta, BL Kamatani, Y Kato, N Kooner, JS Laakso, M Leander, K Lehtimäki, T Magnusson, PKE Penninx, B Pereira, AC Rauramaa, R Samani, NJ Scott, J Shu, X-O van der Harst, P Wagenknecht, LE Wang, YX Wareham, NJ Weir, DR Wickremasinghe, AR Zheng, W Elliott, P North, KE Bouchard, C Evans, MK Gudnason, V Liu, C-T Liu, Y Psaty, BM Ridker, PM van Dam, RM Kardia, SLR Zhu, X Rotimi, CN Mook-Kanamori, DO Fornage, M Kelly, TN Fox, ER Hayward, C van Duijn, CM Tai, ES Wong, TY Liu, J Rotter, JI Gauderman, WJ Province, MA Munroe, PB Rice, K Chasman, DI Cupples, LA Rao, DC Morrison, AC
author_sort	de Vries, PS
collection	OXFORD
description	A person’s lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014–November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2–degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 × 10−6) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 × 10−8 using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.
first_indexed	2024-03-07T04:35:06Z
format	Journal article
id	oxford-uuid:cfa9958b-696c-44de-ad2e-a22f3bd86c7f
institution	University of Oxford
language	English
last_indexed	2024-03-07T04:35:06Z
publishDate	2019
publisher	Oxford University Press
record_format	dspace
spelling	oxford-uuid:cfa9958b-696c-44de-ad2e-a22f3bd86c7f2022-03-27T07:45:18ZMultiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactionsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:cfa9958b-696c-44de-ad2e-a22f3bd86c7fEnglishSymplectic Elements at OxfordOxford University Press2019de Vries, PSWatkins, HBrown, MRBentley, ARSung, YJWinkler, TWNtalla, ISchwander, KKraja, ATGuo, XInterAct ConsortiumFranceschini, NCheng, C-YSim, XVojinovic, DHuffman, JEMusani, SKLi, CFeitosa, MFRichard, MANoordam, RAschard, HBartz, TMBielak, LFDeng, XDorajoo, RLohman, KKManning, AKRankinen, TSmith, AVTajuddin, SMEvangelou, EGraff, MAlver, MBoissel, MChai, JFChen, XDivers, JGandin, IGao, CGoel, AHagemeijer, YHarris, SEHartwig, FPHe, MHorimoto, ARVRHsu, F-CJackson, AUKasturiratne, AKomulainen, PKühnel, BLaguzzi, FLee, JHLuan, JLyytikäinen, L-PMatoba, NNolte, IMPietzner, MRiaz, MSaid, MAScott, RASofer, TStančáková, ATakeuchi, FTayo, BOvan der Most, PJVarga, TVWang, YWare, EBWen, WYanek, LRZhang, WZhao, JHAfaq, SAmin, NAmini, MArking, DEAung, TBallantyne, CBoerwinkle, EBroeckel, UCampbell, ACanouil, MCharumathi, SChen, Y-DIConnell, JMde Faire, Ude Las Fuentes, Lde Mutsert, Rde Silva, HJDing, JDominiczak, AFDuan, QEaton, CBEppinga, RNFaul, JDFisher, VForrester, TFranco, OHFriedlander, YGhanbari, MGiulianini, FGrabe, HJGrove, MLGu, CCHarris, TBHeikkinen, SHeng, C-KHirata, MHixson, JEHoward, BVIkram, MAJacobs, DRJohnson, CJonas, JBKammerer, CMKatsuya, TKhor, CCKilpeläinen, TOKoh, W-PKoistinen, HAKolcic, IKooperberg, CKrieger, JEKritchevsky, SBKubo, MKuusisto, JLakka, TALangefeld, CDLangenberg, CLauner, LJLehne, BLemaitre, RNLi, YLiang, JLiu, JLiu, KLoh, MLouie, TMägi, RManichaikul, AWMcKenzie, CAMeitinger, TMetspalu, AMilaneschi, YMilani, LMohlke, KLMosley, THMukamal, KJNalls, MANauck, MNelson, CPSotoodehnia, NO'Connell, JRPalmer, NDPazoki, RPedersen, NLPeters, APeyser, PAPolasek, OPoulter, NRaffel, LJRaitakari, OTReiner, APRice, TKRich, SSRobino, ARobinson, JGRose, LMRudan, ISchmidt, COSchreiner, PJScott, WRSever, PShi, YSidney, SSims, MSmith, BHSmith, JASnieder, HStarr, JMStrauch, KTan, NTaylor, KDTeo, YYTham, YCUitterlinden, AGvan Heemst, DVuckovic, DWaldenberger, MWang, LWang, YWang, ZWei, WBWilliams, CWilson, GWojczynski, MKYao, JYu, BYu, CYuan, J-MZhao, WZonderman, ABBecker, DMBoehnke, MBowden, DWChambers, JCDeary, IJEsko, TFarrall, MFranks, PWFreedman, BIFroguel, PGasparini, PGieger, CHorta, BLKamatani, YKato, NKooner, JSLaakso, MLeander, KLehtimäki, TMagnusson, PKEPenninx, BPereira, ACRauramaa, RSamani, NJScott, JShu, X-Ovan der Harst, PWagenknecht, LEWang, YXWareham, NJWeir, DRWickremasinghe, ARZheng, WElliott, PNorth, KEBouchard, CEvans, MKGudnason, VLiu, C-TLiu, YPsaty, BMRidker, PMvan Dam, RMKardia, SLRZhu, XRotimi, CNMook-Kanamori, DOFornage, MKelly, TNFox, ERHayward, Cvan Duijn, CMTai, ESWong, TYLiu, JRotter, JIGauderman, WJProvince, MAMunroe, PBRice, KChasman, DICupples, LARao, DCMorrison, ACLifelines Cohort, Groningen, The Netherlands (Lifelines Cohort Study),A person’s lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014–November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2–degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 × 10−6) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 × 10−8 using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models.
spellingShingle	de Vries, PS Watkins, H Brown, MR Bentley, AR Sung, YJ Winkler, TW Ntalla, I Schwander, K Kraja, AT Guo, X InterAct Consortium Franceschini, N Cheng, C-Y Sim, X Vojinovic, D Huffman, JE Musani, SK Li, C Feitosa, MF Richard, MA Noordam, R Aschard, H Bartz, TM Bielak, LF Deng, X Dorajoo, R Lohman, KK Manning, AK Rankinen, T Smith, AV Tajuddin, SM Evangelou, E Graff, M Alver, M Boissel, M Chai, JF Chen, X Divers, J Gandin, I Gao, C Goel, A Hagemeijer, Y Harris, SE Hartwig, FP He, M Horimoto, ARVR Hsu, F-C Jackson, AU Kasturiratne, A Komulainen, P Kühnel, B Laguzzi, F Lee, JH Luan, J Lyytikäinen, L-P Matoba, N Nolte, IM Pietzner, M Riaz, M Said, MA Scott, RA Sofer, T Stančáková, A Takeuchi, F Tayo, BO van der Most, PJ Varga, TV Wang, Y Ware, EB Wen, W Yanek, LR Zhang, W Zhao, JH Afaq, S Amin, N Amini, M Arking, DE Aung, T Ballantyne, C Boerwinkle, E Broeckel, U Campbell, A Canouil, M Charumathi, S Chen, Y-DI Connell, JM de Faire, U de Las Fuentes, L de Mutsert, R de Silva, HJ Ding, J Dominiczak, AF Duan, Q Eaton, CB Eppinga, RN Faul, JD Fisher, V Forrester, T Franco, OH Friedlander, Y Ghanbari, M Giulianini, F Grabe, HJ Grove, ML Gu, CC Harris, TB Heikkinen, S Heng, C-K Hirata, M Hixson, JE Howard, BV Ikram, MA Jacobs, DR Johnson, C Jonas, JB Kammerer, CM Katsuya, T Khor, CC Kilpeläinen, TO Koh, W-P Koistinen, HA Kolcic, I Kooperberg, C Krieger, JE Kritchevsky, SB Kubo, M Kuusisto, J Lakka, TA Langefeld, CD Langenberg, C Launer, LJ Lehne, B Lemaitre, RN Li, Y Liang, J Liu, J Liu, K Loh, M Louie, T Mägi, R Manichaikul, AW McKenzie, CA Meitinger, T Metspalu, A Milaneschi, Y Milani, L Mohlke, KL Mosley, TH Mukamal, KJ Nalls, MA Nauck, M Nelson, CP Sotoodehnia, N O'Connell, JR Palmer, ND Pazoki, R Pedersen, NL Peters, A Peyser, PA Polasek, O Poulter, N Raffel, LJ Raitakari, OT Reiner, AP Rice, TK Rich, SS Robino, A Robinson, JG Rose, LM Rudan, I Schmidt, CO Schreiner, PJ Scott, WR Sever, P Shi, Y Sidney, S Sims, M Smith, BH Smith, JA Snieder, H Starr, JM Strauch, K Tan, N Taylor, KD Teo, YY Tham, YC Uitterlinden, AG van Heemst, D Vuckovic, D Waldenberger, M Wang, L Wang, Y Wang, Z Wei, WB Williams, C Wilson, G Wojczynski, MK Yao, J Yu, B Yu, C Yuan, J-M Zhao, W Zonderman, AB Becker, DM Boehnke, M Bowden, DW Chambers, JC Deary, IJ Esko, T Farrall, M Franks, PW Freedman, BI Froguel, P Gasparini, P Gieger, C Horta, BL Kamatani, Y Kato, N Kooner, JS Laakso, M Leander, K Lehtimäki, T Magnusson, PKE Penninx, B Pereira, AC Rauramaa, R Samani, NJ Scott, J Shu, X-O van der Harst, P Wagenknecht, LE Wang, YX Wareham, NJ Weir, DR Wickremasinghe, AR Zheng, W Elliott, P North, KE Bouchard, C Evans, MK Gudnason, V Liu, C-T Liu, Y Psaty, BM Ridker, PM van Dam, RM Kardia, SLR Zhu, X Rotimi, CN Mook-Kanamori, DO Fornage, M Kelly, TN Fox, ER Hayward, C van Duijn, CM Tai, ES Wong, TY Liu, J Rotter, JI Gauderman, WJ Province, MA Munroe, PB Rice, K Chasman, DI Cupples, LA Rao, DC Morrison, AC Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions
title	Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions
title_full	Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions
title_fullStr	Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions
title_full_unstemmed	Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions
title_short	Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions
title_sort	multiancestry genome wide association study of lipid levels incorporating gene alcohol interactions
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raodc multiancestrygenomewideassociationstudyoflipidlevelsincorporatinggenealcoholinteractions AT morrisonac multiancestrygenomewideassociationstudyoflipidlevelsincorporatinggenealcoholinteractions

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