ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.

ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.

Epithelial to mesenchymal transition (EMT), and the reverse mesenchymal to epithelial transition (MET), are known examples of epithelial plasticity that are important in kidney development and cancer metastasis. Here we identify ASPP2, a haploinsufficient tumour suppressor, p53 activator and PAR3 bi...

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Autors principals: Wang, Y, Bu, F, Royer, C, Serres, S, Larkin, JR, Soto, MS, Sibson, N, Salter, V, Fritzsche, F, Turnquist, C, Koch, S, Zak, J, Zhong, S, Wu, G, Liang, A, Olofsen, P, Moch, H, Hancock, D, Downward, J, Goldin, R, Zhao, J, Tong, X, Guo, Y, Lu, X
Format: Journal article
Idioma:English
Publicat: Nature Publishing Group 2014

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