A Bayesian approach using covariance of single nucleotide polymorphism data to detect differences in linkage disequilibrium patterns between groups of individuals.

MOTIVATION: Quantifying differences in linkage disequilibrium (LD) between sub-groups can highlight genetic regions or sites under selection and/or associated with disease, and may have utility in trans-ethnic mapping studies. RESULTS: We present a novel pseudo Bayes factor (PBF) approach that asses...

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Príomhchruthaitheoirí: Clark, T, Campino, S, Anastasi, E, Auburn, S, Teo, Y, Small, K, Rockett, K, Kwiatkowski, D, Holmes, C
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: 2010