A mouse model for spondyloepiphyseal dysplasia congenita with secondary osteoarthritis due to a Col2a1 mutation.
Progeny of mice treated with the mutagen N-ethyl-N-nitrosourea (ENU) revealed a mouse, designated Longpockets (Lpk), with short humeri, abnormal vertebrae, and disorganized growth plates, features consistent with spondyloepiphyseal dysplasia congenita (SEDC). The Lpk phenotype was inherited as an au...
Main Authors: | Esapa, C, Hough, T, Testori, S, Head, R, Crane, E, Chan, C, Evans, H, Bassett, J, Tylzanowski, P, McNally, E, Carr, A, Boyde, A, Howell, P, Clark, A, Williams, G, Brown, M, Croucher, P, Nesbit, M, Brown, S, Cox, R, Cheeseman, M, Thakker, R |
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Format: | Journal article |
Language: | English |
Published: |
2012
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