A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation
<p>Inhibition of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome has recently emerged as a promising therapeutic target for several inflammatory diseases. After priming and activation by inflammation triggers, NLRP3 forms a complex with apoptosis-associated speck-like...
Main Authors: | Nizami, S, Millar, V, Arunasalam, K, Zarganes-Tzitzikas, T, Brough, D, Tresadern, G, Brennan, PE, Davis, JB, Ebner, D, Di Daniel, E |
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Format: | Journal article |
Language: | English |
Published: |
Springer Nature
2021
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