Structural determinants of conformationally selective, prion-binding aptamers.

We have recently described the isolation of 2'-fluoropyrimidine-substituted RNA aptamers that bind selectively to disease-associated beta-sheet-rich forms of the prion protein, PrP, from a number of mammalian species. These aptamers inhibit the accumulation of protease-resistant forms of PrP in...

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Main Authors: Sayer, N, Cubin, M, Rhie, A, Bullock, M, Tahiri-Alaoui, A, James, W
格式: Journal article
语言:English
出版: 2004