Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis.
Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. As little is conclusively known about MS disease mechanisms, we have selected a variety of candidate genes that may influence the prognosis of the disease based...
| Huvudupphovsmän: | , , , , , , , , , , , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
2008
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| _version_ | 1826297758878793728 |
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| author | Ramagopalan, S Deluca, G Morrison, K Herrera, B Dyment, D Lincoln, MR Orton, S Chao, M Degenhardt, A Pugliatti, M Sadovnick, A Sotgiu, S Ebers, G |
| author_facet | Ramagopalan, S Deluca, G Morrison, K Herrera, B Dyment, D Lincoln, MR Orton, S Chao, M Degenhardt, A Pugliatti, M Sadovnick, A Sotgiu, S Ebers, G |
| author_sort | Ramagopalan, S |
| collection | OXFORD |
| description | Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. As little is conclusively known about MS disease mechanisms, we have selected a variety of candidate genes that may influence the prognosis of the disease based on their function. A cohort of sporadic MS cases, taken from opposite extremes of the putative distribution of long-term outcome using the most stringent clinical criteria to date, was used to determine the role of on MS disease severity. The MS cases selected represent the prognostic best 5 % (benign MS) and worst 5 % (malignant MS) of cases in terms of clinical outcome assessed by the EDSS. Genotyping the two sets of MS patients (112 benign and 51 malignant) and a replication cohort from Sardinia provided no evidence to suggest that the genes selected have any outcome modifying activity, although small effects of these genes cannot be ruled out. |
| first_indexed | 2024-03-07T04:36:33Z |
| format | Journal article |
| id | oxford-uuid:d01ed50f-e399-4eb4-923c-67b33d8109d3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:36:33Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:d01ed50f-e399-4eb4-923c-67b33d8109d32022-03-27T07:47:51ZAnalysis of 45 candidate genes for disease modifying activity in multiple sclerosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d01ed50f-e399-4eb4-923c-67b33d8109d3EnglishSymplectic Elements at Oxford2008Ramagopalan, SDeluca, GMorrison, KHerrera, BDyment, DLincoln, MROrton, SChao, MDegenhardt, APugliatti, MSadovnick, ASotgiu, SEbers, GMultiple sclerosis (MS) is a common inflammatory disease of the central nervous system unsurpassed for its variability in disease outcome. As little is conclusively known about MS disease mechanisms, we have selected a variety of candidate genes that may influence the prognosis of the disease based on their function. A cohort of sporadic MS cases, taken from opposite extremes of the putative distribution of long-term outcome using the most stringent clinical criteria to date, was used to determine the role of on MS disease severity. The MS cases selected represent the prognostic best 5 % (benign MS) and worst 5 % (malignant MS) of cases in terms of clinical outcome assessed by the EDSS. Genotyping the two sets of MS patients (112 benign and 51 malignant) and a replication cohort from Sardinia provided no evidence to suggest that the genes selected have any outcome modifying activity, although small effects of these genes cannot be ruled out. |
| spellingShingle | Ramagopalan, S Deluca, G Morrison, K Herrera, B Dyment, D Lincoln, MR Orton, S Chao, M Degenhardt, A Pugliatti, M Sadovnick, A Sotgiu, S Ebers, G Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis. |
| title | Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis. |
| title_full | Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis. |
| title_fullStr | Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis. |
| title_full_unstemmed | Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis. |
| title_short | Analysis of 45 candidate genes for disease modifying activity in multiple sclerosis. |
| title_sort | analysis of 45 candidate genes for disease modifying activity in multiple sclerosis |
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