Sumatriptan decreases food intake and increases plasma growth hormone in healthy women.
We studied the effect of the 5-HT1B/ID receptor agonist sumatriptan (6 mg s.c.) on plasma growth hormone and prolactin and food intake in 15 healthy female subjects using a double-blind, placebo-controlled, cross-over design. Sumatriptan significantly elevated plasma growth hormone but did not alter...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1826297764275814400 |
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| author | Boeles, S Williams, C Campling, G Goodall, E Cowen, P |
| author_facet | Boeles, S Williams, C Campling, G Goodall, E Cowen, P |
| author_sort | Boeles, S |
| collection | OXFORD |
| description | We studied the effect of the 5-HT1B/ID receptor agonist sumatriptan (6 mg s.c.) on plasma growth hormone and prolactin and food intake in 15 healthy female subjects using a double-blind, placebo-controlled, cross-over design. Sumatriptan significantly elevated plasma growth hormone but did not alter plasma prolactin. Sumatriptan also significantly lowered total food intake in a buffet meal, particularly decreasing the intake of fat. Our results indicate that 5-HT1B/ID receptors may be involved in the regulation of food intake in humans. In addition, while activation of 5-HT1B/ID receptors stimulates growth hormone release in both men and women, sumatriptan lowers plasma prolactin only in men, suggesting sex differences in the 5-HT regulation of prolactin release. |
| first_indexed | 2024-03-07T04:36:38Z |
| format | Journal article |
| id | oxford-uuid:d0269b13-1d48-47c9-990d-f025f7642877 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:36:38Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:d0269b13-1d48-47c9-990d-f025f76428772022-03-27T07:47:57ZSumatriptan decreases food intake and increases plasma growth hormone in healthy women.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d0269b13-1d48-47c9-990d-f025f7642877EnglishSymplectic Elements at Oxford1997Boeles, SWilliams, CCampling, GGoodall, ECowen, PWe studied the effect of the 5-HT1B/ID receptor agonist sumatriptan (6 mg s.c.) on plasma growth hormone and prolactin and food intake in 15 healthy female subjects using a double-blind, placebo-controlled, cross-over design. Sumatriptan significantly elevated plasma growth hormone but did not alter plasma prolactin. Sumatriptan also significantly lowered total food intake in a buffet meal, particularly decreasing the intake of fat. Our results indicate that 5-HT1B/ID receptors may be involved in the regulation of food intake in humans. In addition, while activation of 5-HT1B/ID receptors stimulates growth hormone release in both men and women, sumatriptan lowers plasma prolactin only in men, suggesting sex differences in the 5-HT regulation of prolactin release. |
| spellingShingle | Boeles, S Williams, C Campling, G Goodall, E Cowen, P Sumatriptan decreases food intake and increases plasma growth hormone in healthy women. |
| title | Sumatriptan decreases food intake and increases plasma growth hormone in healthy women. |
| title_full | Sumatriptan decreases food intake and increases plasma growth hormone in healthy women. |
| title_fullStr | Sumatriptan decreases food intake and increases plasma growth hormone in healthy women. |
| title_full_unstemmed | Sumatriptan decreases food intake and increases plasma growth hormone in healthy women. |
| title_short | Sumatriptan decreases food intake and increases plasma growth hormone in healthy women. |
| title_sort | sumatriptan decreases food intake and increases plasma growth hormone in healthy women |
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