Immunoglobulin superfamily cell adhesion molecules: zippers and signals.
The latest structural studies of immunoglobulin superfamily cell adhesion molecules are driving a shift in perspective; increasingly the view is not focused solely on the individual molecule but rather is on the molecular assembly. Two common themes are emerging, revealing mechanisms for ectodomain-...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1826297767154155520 |
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| author | Aricescu, A Jones, E |
| author_facet | Aricescu, A Jones, E |
| author_sort | Aricescu, A |
| collection | OXFORD |
| description | The latest structural studies of immunoglobulin superfamily cell adhesion molecules are driving a shift in perspective; increasingly the view is not focused solely on the individual molecule but rather is on the molecular assembly. Two common themes are emerging, revealing mechanisms for ectodomain-dependent regulation of cell surface receptors' signalling abilities. The first is the propensity of many such molecules to arrange in zipper-type or array-type assemblies driven by a network of highly specific cis and trans interactions. The second is the use of the extracellular dimensions of a molecule or adhesion complex as properties which, in combination with characteristic intercellular spacings, can determine the co-localisation or exclusion of particular protein populations at cell interfaces and junctions. |
| first_indexed | 2024-03-07T04:36:40Z |
| format | Journal article |
| id | oxford-uuid:d0298fe9-ab3d-4915-989c-b44c9c7caa00 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:36:40Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:d0298fe9-ab3d-4915-989c-b44c9c7caa002022-03-27T07:48:02ZImmunoglobulin superfamily cell adhesion molecules: zippers and signals.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d0298fe9-ab3d-4915-989c-b44c9c7caa00EnglishSymplectic Elements at Oxford2007Aricescu, AJones, EThe latest structural studies of immunoglobulin superfamily cell adhesion molecules are driving a shift in perspective; increasingly the view is not focused solely on the individual molecule but rather is on the molecular assembly. Two common themes are emerging, revealing mechanisms for ectodomain-dependent regulation of cell surface receptors' signalling abilities. The first is the propensity of many such molecules to arrange in zipper-type or array-type assemblies driven by a network of highly specific cis and trans interactions. The second is the use of the extracellular dimensions of a molecule or adhesion complex as properties which, in combination with characteristic intercellular spacings, can determine the co-localisation or exclusion of particular protein populations at cell interfaces and junctions. |
| spellingShingle | Aricescu, A Jones, E Immunoglobulin superfamily cell adhesion molecules: zippers and signals. |
| title | Immunoglobulin superfamily cell adhesion molecules: zippers and signals. |
| title_full | Immunoglobulin superfamily cell adhesion molecules: zippers and signals. |
| title_fullStr | Immunoglobulin superfamily cell adhesion molecules: zippers and signals. |
| title_full_unstemmed | Immunoglobulin superfamily cell adhesion molecules: zippers and signals. |
| title_short | Immunoglobulin superfamily cell adhesion molecules: zippers and signals. |
| title_sort | immunoglobulin superfamily cell adhesion molecules zippers and signals |
| work_keys_str_mv | AT aricescua immunoglobulinsuperfamilycelladhesionmoleculeszippersandsignals AT jonese immunoglobulinsuperfamilycelladhesionmoleculeszippersandsignals |