Molecular mechanisms of sexually dimorphic nervous system patterning in flies and worms
Male and female brains display anatomical and functional differences. Such differences are observed in species across the animal kingdom, including humans, but have been particularly well-studied in two classic animal model systems, the fruit fly Drosophila melanogaster and the nematode Caenorhabdit...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Annual Reviews
2021
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| _version_ | 1797096109003243520 |
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| author | Goodwin, SF Hobert, O |
| author_facet | Goodwin, SF Hobert, O |
| author_sort | Goodwin, SF |
| collection | OXFORD |
| description | Male and female brains display anatomical and functional differences. Such differences are observed in species across the animal kingdom, including humans, but have been particularly well-studied in two classic animal model systems, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans. Here we summarize recent advances in understanding how the worm and fly brain acquire sexually dimorphic features during development. We highlight the advantages of each system, illustrating how the precise anatomical delineation of sexual dimorphisms in worms has enabled recent analysis into how these dimorphisms become specified during development, and how focusing on sexually dimorphic neurons in the fly has enabled an increasingly detailed understanding of sex-specific behaviors. |
| first_indexed | 2024-03-07T04:37:21Z |
| format | Journal article |
| id | oxford-uuid:d06aa158-1ec8-4453-a915-3b02036e1bbc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:37:21Z |
| publishDate | 2021 |
| publisher | Annual Reviews |
| record_format | dspace |
| spelling | oxford-uuid:d06aa158-1ec8-4453-a915-3b02036e1bbc2022-03-27T07:49:41ZMolecular mechanisms of sexually dimorphic nervous system patterning in flies and wormsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d06aa158-1ec8-4453-a915-3b02036e1bbcEnglishSymplectic ElementsAnnual Reviews2021Goodwin, SFHobert, OMale and female brains display anatomical and functional differences. Such differences are observed in species across the animal kingdom, including humans, but have been particularly well-studied in two classic animal model systems, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans. Here we summarize recent advances in understanding how the worm and fly brain acquire sexually dimorphic features during development. We highlight the advantages of each system, illustrating how the precise anatomical delineation of sexual dimorphisms in worms has enabled recent analysis into how these dimorphisms become specified during development, and how focusing on sexually dimorphic neurons in the fly has enabled an increasingly detailed understanding of sex-specific behaviors. |
| spellingShingle | Goodwin, SF Hobert, O Molecular mechanisms of sexually dimorphic nervous system patterning in flies and worms |
| title | Molecular mechanisms of sexually dimorphic nervous system patterning in flies and worms |
| title_full | Molecular mechanisms of sexually dimorphic nervous system patterning in flies and worms |
| title_fullStr | Molecular mechanisms of sexually dimorphic nervous system patterning in flies and worms |
| title_full_unstemmed | Molecular mechanisms of sexually dimorphic nervous system patterning in flies and worms |
| title_short | Molecular mechanisms of sexually dimorphic nervous system patterning in flies and worms |
| title_sort | molecular mechanisms of sexually dimorphic nervous system patterning in flies and worms |
| work_keys_str_mv | AT goodwinsf molecularmechanismsofsexuallydimorphicnervoussystempatterninginfliesandworms AT hoberto molecularmechanismsofsexuallydimorphicnervoussystempatterninginfliesandworms |