Matrix metallopropteinases in heart failure.
Heart failure (HF) represents a complex multifactorial syndrome, characterized by crucial structural and functional abnormalities of the myocardium. Matrix metalloproteinases are associated with left ventricular dysfunction, adverse left ventricular remodelling and prognosis after acute myocardial i...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797096111034335232 |
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| author | Tousoulis, D Kampoli, A Papageorgiou, N Antoniades, C Siasos, G Latsios, G Tsiamis, E Stefanadis, C |
| author_facet | Tousoulis, D Kampoli, A Papageorgiou, N Antoniades, C Siasos, G Latsios, G Tsiamis, E Stefanadis, C |
| author_sort | Tousoulis, D |
| collection | OXFORD |
| description | Heart failure (HF) represents a complex multifactorial syndrome, characterized by crucial structural and functional abnormalities of the myocardium. Matrix metalloproteinases are associated with left ventricular dysfunction, adverse left ventricular remodelling and prognosis after acute myocardial infarction. There is a strong association between oxidative stress and MMPs in the pathophysiology of HF. As MMPs are strongly associated to the pathogenesis and pathophysiology of HF, several agents have been proposed as potential modulators of these molecules. Classical agents such as statins, angiotensin converting enzyme inhibitors (ACEIS) and beta-blockers and a variety of novel agents have been implicated in the pathogenesis and progression of heart failure via the matrix metalloproteinases pathway and consist of possible future therapeutic targets. |
| first_indexed | 2024-03-07T04:37:22Z |
| format | Journal article |
| id | oxford-uuid:d06d7c3b-d2e9-4964-bcdf-333d9ec4646f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:37:22Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:d06d7c3b-d2e9-4964-bcdf-333d9ec4646f2022-03-27T07:49:48ZMatrix metallopropteinases in heart failure.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d06d7c3b-d2e9-4964-bcdf-333d9ec4646fEnglishSymplectic Elements at Oxford2012Tousoulis, DKampoli, APapageorgiou, NAntoniades, CSiasos, GLatsios, GTsiamis, EStefanadis, CHeart failure (HF) represents a complex multifactorial syndrome, characterized by crucial structural and functional abnormalities of the myocardium. Matrix metalloproteinases are associated with left ventricular dysfunction, adverse left ventricular remodelling and prognosis after acute myocardial infarction. There is a strong association between oxidative stress and MMPs in the pathophysiology of HF. As MMPs are strongly associated to the pathogenesis and pathophysiology of HF, several agents have been proposed as potential modulators of these molecules. Classical agents such as statins, angiotensin converting enzyme inhibitors (ACEIS) and beta-blockers and a variety of novel agents have been implicated in the pathogenesis and progression of heart failure via the matrix metalloproteinases pathway and consist of possible future therapeutic targets. |
| spellingShingle | Tousoulis, D Kampoli, A Papageorgiou, N Antoniades, C Siasos, G Latsios, G Tsiamis, E Stefanadis, C Matrix metallopropteinases in heart failure. |
| title | Matrix metallopropteinases in heart failure. |
| title_full | Matrix metallopropteinases in heart failure. |
| title_fullStr | Matrix metallopropteinases in heart failure. |
| title_full_unstemmed | Matrix metallopropteinases in heart failure. |
| title_short | Matrix metallopropteinases in heart failure. |
| title_sort | matrix metallopropteinases in heart failure |
| work_keys_str_mv | AT tousoulisd matrixmetallopropteinasesinheartfailure AT kampolia matrixmetallopropteinasesinheartfailure AT papageorgioun matrixmetallopropteinasesinheartfailure AT antoniadesc matrixmetallopropteinasesinheartfailure AT siasosg matrixmetallopropteinasesinheartfailure AT latsiosg matrixmetallopropteinasesinheartfailure AT tsiamise matrixmetallopropteinasesinheartfailure AT stefanadisc matrixmetallopropteinasesinheartfailure |