Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.

Nitroreductase: a prodrug-activating enzyme for cancer gene therapy.

1. The prodrug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) is activated by Escherichia coli nitroreductase (NTR) to a potent DNA-crosslinking agent. 2. Virus-mediated expression of NTR in tumour cells sensitizes them to CB1954 in vitro and in vivo, providing the basis for a strategy of cancer ge...

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Bibliographic Details
Main Authors:	Searle, P, Chen, M, Hu, L, Race, P, Lovering, A, Grove, J, Guise, C, Jaberipour, M, James, N, Mautner, V, Young, L, Kerr, D, Mountain, A, White, SA, Hyde, E
Format:	Journal article
Language:	English
Published:	2004

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