Combining statistical alignment and phylogenetic footprinting to detect regulatory elements.
MOTIVATION: Traditional alignment-based phylogenetic footprinting approaches make predictions on the basis of a single assumed alignment. The predictions are therefore highly sensitive to alignment errors or regions of alignment uncertainty. Alternatively, statistical alignment methods provide a fr...
Main Authors: | Satija, R, Pachter, L, Hein, J |
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Format: | Journal article |
Language: | English |
Published: |
2008
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