Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues.
Enantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the tetrafluorinated ethylene group is compatible with O-phosphorylation of the primary alcohol, as demonstrated by the successful preparation of...
Main Authors: | Bonnac, L, Lee, SE, Giuffredi, G, Elphick, L, Anderson, A, Child, E, Mann, D, Gouverneur, V |
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Format: | Journal article |
Language: | English |
Published: |
2010
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