Lessons from the study of T-cell differentiation in persistent human virus infection.
Confusion surrounds the current classification of memory and effector T-cell subsets and there is a lack of consistency in the use of these terms between human and murine studies. The development of peptide-HLA tetrameric complexes ("tetramers") that accurately identify virus-specific T ce...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1826297884200402944 |
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| author | Appay, V Rowland-Jones, S |
| author_facet | Appay, V Rowland-Jones, S |
| author_sort | Appay, V |
| collection | OXFORD |
| description | Confusion surrounds the current classification of memory and effector T-cell subsets and there is a lack of consistency in the use of these terms between human and murine studies. The development of peptide-HLA tetrameric complexes ("tetramers") that accurately identify virus-specific T cells and can be used with a range of cell surface and intra-cellular markers has provided further insights in our understanding of the process of T-cell differentiation, or post-thymic development. We propose that T-cell differentiation subsets in human viral infection should be regarded as distinct from the current definitions of memory and effector cells; further work is needed to reveal the role of the differentiation process in anti-viral immunity. |
| first_indexed | 2024-03-07T04:38:26Z |
| format | Journal article |
| id | oxford-uuid:d0c80000-a755-4c49-a357-70906fb26d9d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:38:26Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:d0c80000-a755-4c49-a357-70906fb26d9d2022-03-27T07:52:25ZLessons from the study of T-cell differentiation in persistent human virus infection.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d0c80000-a755-4c49-a357-70906fb26d9dEnglishSymplectic Elements at Oxford2004Appay, VRowland-Jones, SConfusion surrounds the current classification of memory and effector T-cell subsets and there is a lack of consistency in the use of these terms between human and murine studies. The development of peptide-HLA tetrameric complexes ("tetramers") that accurately identify virus-specific T cells and can be used with a range of cell surface and intra-cellular markers has provided further insights in our understanding of the process of T-cell differentiation, or post-thymic development. We propose that T-cell differentiation subsets in human viral infection should be regarded as distinct from the current definitions of memory and effector cells; further work is needed to reveal the role of the differentiation process in anti-viral immunity. |
| spellingShingle | Appay, V Rowland-Jones, S Lessons from the study of T-cell differentiation in persistent human virus infection. |
| title | Lessons from the study of T-cell differentiation in persistent human virus infection. |
| title_full | Lessons from the study of T-cell differentiation in persistent human virus infection. |
| title_fullStr | Lessons from the study of T-cell differentiation in persistent human virus infection. |
| title_full_unstemmed | Lessons from the study of T-cell differentiation in persistent human virus infection. |
| title_short | Lessons from the study of T-cell differentiation in persistent human virus infection. |
| title_sort | lessons from the study of t cell differentiation in persistent human virus infection |
| work_keys_str_mv | AT appayv lessonsfromthestudyoftcelldifferentiationinpersistenthumanvirusinfection AT rowlandjoness lessonsfromthestudyoftcelldifferentiationinpersistenthumanvirusinfection |