Obesity and the relative risk of replacement surgery in knee osteoarthritis patients: A prospective cohort study.
<strong>Objective:</strong> It is unclear what the impact of obesity has on the progression of knee osteoarthritis (KOA), from diagnosis to knee replacement (KR) surgery. This research examines the relative risk of KR surgery in overweight/obese patients with newly diagnosed knee osteoar...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal article |
| Published: |
Wiley
2015
|
| _version_ | 1797096189433217024 |
|---|---|
| author | Leyland, K Judge, A Diez-Perez, A Carr, A Cooper, C Arden, N Prieto-Alhambra, D Javaid, M |
| author_facet | Leyland, K Judge, A Diez-Perez, A Carr, A Cooper, C Arden, N Prieto-Alhambra, D Javaid, M |
| author_sort | Leyland, K |
| collection | OXFORD |
| description | <strong>Objective:</strong> It is unclear what the impact of obesity has on the progression of knee osteoarthritis (KOA), from diagnosis to knee replacement (KR) surgery. This research examines the relative risk of KR surgery in overweight/obese patients with newly diagnosed knee osteoarthritis in a community population. <strong>Methods:</strong> Subjects were selected from the SIDIAP database, which compiles comprehensive clinical information collected by healthcare professionals for 80% of the population of Catalonia, Spain (>5.5 million people). Patients newly diagnosed with KOA in primary care between 2006 and 2011 were included. KR was ascertained using ICD-9-CM codes from linked hospital admissions data. Multivariable Cox regression models were fitted for KR according to BMI, and were adjusted for relevant confounders. Population proportional attributable risk was calculated. <strong>Results:</strong> 105,189 participants were followed up for a median (inter-quartile range) of 2.6 (1.3-4.2) years. 7,512 (7.1%) patients underwent KR. Adjusted HRs for KR were: 1.41 (95% CI 1.27 to 1.57) for overweight, 1.97 (1.78 to 2.18) for obese I, 2.39 (2.15 to 2.67) for obese II, and 2.67 (2.34 to 3.04) for obese III compared to normal-weight. The effect of BMI on risk of KR was stronger amongst younger participants. The population attributable risk of obesity for KOA-related KR is 31.0%. <strong>Conclusion:</strong> Overweight and obese patients are at over 40% and 100% increased risk of KR surgery compared to normal-weight respectively. This association is even stronger in younger patients. Weight reduction strategies could potentially reduce the need for KR surgery by 31% amongst KOA patients. This article is protected by copyright. All rights reserved. |
| first_indexed | 2024-03-07T04:38:32Z |
| format | Journal article |
| id | oxford-uuid:d0d2716a-7748-4874-886a-c4583ad23254 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T04:38:32Z |
| publishDate | 2015 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:d0d2716a-7748-4874-886a-c4583ad232542022-03-27T07:52:41ZObesity and the relative risk of replacement surgery in knee osteoarthritis patients: A prospective cohort study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d0d2716a-7748-4874-886a-c4583ad23254Symplectic Elements at OxfordWiley2015Leyland, KJudge, ADiez-Perez, ACarr, ACooper, CArden, NPrieto-Alhambra, DJavaid, M<strong>Objective:</strong> It is unclear what the impact of obesity has on the progression of knee osteoarthritis (KOA), from diagnosis to knee replacement (KR) surgery. This research examines the relative risk of KR surgery in overweight/obese patients with newly diagnosed knee osteoarthritis in a community population. <strong>Methods:</strong> Subjects were selected from the SIDIAP database, which compiles comprehensive clinical information collected by healthcare professionals for 80% of the population of Catalonia, Spain (>5.5 million people). Patients newly diagnosed with KOA in primary care between 2006 and 2011 were included. KR was ascertained using ICD-9-CM codes from linked hospital admissions data. Multivariable Cox regression models were fitted for KR according to BMI, and were adjusted for relevant confounders. Population proportional attributable risk was calculated. <strong>Results:</strong> 105,189 participants were followed up for a median (inter-quartile range) of 2.6 (1.3-4.2) years. 7,512 (7.1%) patients underwent KR. Adjusted HRs for KR were: 1.41 (95% CI 1.27 to 1.57) for overweight, 1.97 (1.78 to 2.18) for obese I, 2.39 (2.15 to 2.67) for obese II, and 2.67 (2.34 to 3.04) for obese III compared to normal-weight. The effect of BMI on risk of KR was stronger amongst younger participants. The population attributable risk of obesity for KOA-related KR is 31.0%. <strong>Conclusion:</strong> Overweight and obese patients are at over 40% and 100% increased risk of KR surgery compared to normal-weight respectively. This association is even stronger in younger patients. Weight reduction strategies could potentially reduce the need for KR surgery by 31% amongst KOA patients. This article is protected by copyright. All rights reserved. |
| spellingShingle | Leyland, K Judge, A Diez-Perez, A Carr, A Cooper, C Arden, N Prieto-Alhambra, D Javaid, M Obesity and the relative risk of replacement surgery in knee osteoarthritis patients: A prospective cohort study. |
| title | Obesity and the relative risk of replacement surgery in knee osteoarthritis patients: A prospective cohort study. |
| title_full | Obesity and the relative risk of replacement surgery in knee osteoarthritis patients: A prospective cohort study. |
| title_fullStr | Obesity and the relative risk of replacement surgery in knee osteoarthritis patients: A prospective cohort study. |
| title_full_unstemmed | Obesity and the relative risk of replacement surgery in knee osteoarthritis patients: A prospective cohort study. |
| title_short | Obesity and the relative risk of replacement surgery in knee osteoarthritis patients: A prospective cohort study. |
| title_sort | obesity and the relative risk of replacement surgery in knee osteoarthritis patients a prospective cohort study |
| work_keys_str_mv | AT leylandk obesityandtherelativeriskofreplacementsurgeryinkneeosteoarthritispatientsaprospectivecohortstudy AT judgea obesityandtherelativeriskofreplacementsurgeryinkneeosteoarthritispatientsaprospectivecohortstudy AT diezpereza obesityandtherelativeriskofreplacementsurgeryinkneeosteoarthritispatientsaprospectivecohortstudy AT carra obesityandtherelativeriskofreplacementsurgeryinkneeosteoarthritispatientsaprospectivecohortstudy AT cooperc obesityandtherelativeriskofreplacementsurgeryinkneeosteoarthritispatientsaprospectivecohortstudy AT ardenn obesityandtherelativeriskofreplacementsurgeryinkneeosteoarthritispatientsaprospectivecohortstudy AT prietoalhambrad obesityandtherelativeriskofreplacementsurgeryinkneeosteoarthritispatientsaprospectivecohortstudy AT javaidm obesityandtherelativeriskofreplacementsurgeryinkneeosteoarthritispatientsaprospectivecohortstudy |