Studies on the reaction of glutathione and formaldehyde using NMR.
Within cells it is proposed that a major mechanism for the metabolism of formaldehyde is via its reaction with glutathione (GSH) to form S-hydroxymethylglutathione (HMG), which undergoes subsequent oxidation. In addition to HMG and the previously reported (5R,10S)-5-(carboxymethylcarbamoyl)-7-oxo-3-...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1826297960722333696 |
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| author | Hopkinson, R Barlow, P Schofield, C Claridge, T |
| author_facet | Hopkinson, R Barlow, P Schofield, C Claridge, T |
| author_sort | Hopkinson, R |
| collection | OXFORD |
| description | Within cells it is proposed that a major mechanism for the metabolism of formaldehyde is via its reaction with glutathione (GSH) to form S-hydroxymethylglutathione (HMG), which undergoes subsequent oxidation. In addition to HMG and the previously reported (5R,10S)-5-(carboxymethylcarbamoyl)-7-oxo-3-thia-1,6-diazabicyclo[4.4.1]undecane-10-carboxylic acid (BiGF(2)), NMR studies on the reaction of GSH with formaldehyde reveal two previously unassigned monocyclic structures. The results imply that the biologically relevant reactions between aldehydes and peptides/proteins may be more complex than presently perceived. |
| first_indexed | 2024-03-07T04:39:32Z |
| format | Journal article |
| id | oxford-uuid:d123714c-4616-446b-8cff-fc288e5c6b27 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:39:32Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:d123714c-4616-446b-8cff-fc288e5c6b272022-03-27T07:54:59ZStudies on the reaction of glutathione and formaldehyde using NMR.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d123714c-4616-446b-8cff-fc288e5c6b27EnglishSymplectic Elements at Oxford2010Hopkinson, RBarlow, PSchofield, CClaridge, TWithin cells it is proposed that a major mechanism for the metabolism of formaldehyde is via its reaction with glutathione (GSH) to form S-hydroxymethylglutathione (HMG), which undergoes subsequent oxidation. In addition to HMG and the previously reported (5R,10S)-5-(carboxymethylcarbamoyl)-7-oxo-3-thia-1,6-diazabicyclo[4.4.1]undecane-10-carboxylic acid (BiGF(2)), NMR studies on the reaction of GSH with formaldehyde reveal two previously unassigned monocyclic structures. The results imply that the biologically relevant reactions between aldehydes and peptides/proteins may be more complex than presently perceived. |
| spellingShingle | Hopkinson, R Barlow, P Schofield, C Claridge, T Studies on the reaction of glutathione and formaldehyde using NMR. |
| title | Studies on the reaction of glutathione and formaldehyde using NMR. |
| title_full | Studies on the reaction of glutathione and formaldehyde using NMR. |
| title_fullStr | Studies on the reaction of glutathione and formaldehyde using NMR. |
| title_full_unstemmed | Studies on the reaction of glutathione and formaldehyde using NMR. |
| title_short | Studies on the reaction of glutathione and formaldehyde using NMR. |
| title_sort | studies on the reaction of glutathione and formaldehyde using nmr |
| work_keys_str_mv | AT hopkinsonr studiesonthereactionofglutathioneandformaldehydeusingnmr AT barlowp studiesonthereactionofglutathioneandformaldehydeusingnmr AT schofieldc studiesonthereactionofglutathioneandformaldehydeusingnmr AT claridget studiesonthereactionofglutathioneandformaldehydeusingnmr |