The hippocampus and neocortical inhibitory engrams protect against memory interference
Our experiences often overlap with each other, yet we are able to selectively recall individual memories to guide decisions and future actions. The neural mechanisms that support such precise memory recall remain unclear. Here, using ultra-high field 7T MRI we reveal two distinct mechanisms that pro...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2018
|
| _version_ | 1826298027850072064 |
|---|---|
| author | Koolschijn, R Emir, U Pantelides, A Nili, H Behrens, T Barron, H |
| author_facet | Koolschijn, R Emir, U Pantelides, A Nili, H Behrens, T Barron, H |
| author_sort | Koolschijn, R |
| collection | OXFORD |
| description | Our experiences often overlap with each other, yet we are able to selectively recall individual memories to guide decisions and future actions. The neural mechanisms that support such precise memory recall remain unclear. Here, using ultra-high field 7T MRI we reveal two distinct mechanisms that protect memories from interference. The first mechanism involves the hippocampus, where the blood-oxygen-level-dependent (BOLD) signal predicts behavioral measures of memory interference, and representations of context-dependent memories are pattern separated according to their relational overlap. The second mechanism involves neocortical inhibition. When we reduce the concentration of neocortical GABA using trans-cranial direct current stimulation (tDCS), neocortical memory interference increases in proportion to the reduction in GABA, which in turn predicts behavioral performance. These findings suggest that memory interference is mediated by both the hippocampus and neocortex, where the hippocampus separates overlapping but context-dependent memories using relational information, and neocortical inhibition prevents unwanted co-activation between overlapping memories. |
| first_indexed | 2024-03-07T04:40:34Z |
| format | Journal article |
| id | oxford-uuid:d17d0cae-fea3-426c-bd8e-4ea33de06118 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:40:34Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:d17d0cae-fea3-426c-bd8e-4ea33de061182022-03-27T07:57:22ZThe hippocampus and neocortical inhibitory engrams protect against memory interferenceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d17d0cae-fea3-426c-bd8e-4ea33de06118EnglishSymplectic Elements at OxfordElsevier2018Koolschijn, REmir, UPantelides, ANili, HBehrens, TBarron, HOur experiences often overlap with each other, yet we are able to selectively recall individual memories to guide decisions and future actions. The neural mechanisms that support such precise memory recall remain unclear. Here, using ultra-high field 7T MRI we reveal two distinct mechanisms that protect memories from interference. The first mechanism involves the hippocampus, where the blood-oxygen-level-dependent (BOLD) signal predicts behavioral measures of memory interference, and representations of context-dependent memories are pattern separated according to their relational overlap. The second mechanism involves neocortical inhibition. When we reduce the concentration of neocortical GABA using trans-cranial direct current stimulation (tDCS), neocortical memory interference increases in proportion to the reduction in GABA, which in turn predicts behavioral performance. These findings suggest that memory interference is mediated by both the hippocampus and neocortex, where the hippocampus separates overlapping but context-dependent memories using relational information, and neocortical inhibition prevents unwanted co-activation between overlapping memories. |
| spellingShingle | Koolschijn, R Emir, U Pantelides, A Nili, H Behrens, T Barron, H The hippocampus and neocortical inhibitory engrams protect against memory interference |
| title | The hippocampus and neocortical inhibitory engrams protect against memory interference |
| title_full | The hippocampus and neocortical inhibitory engrams protect against memory interference |
| title_fullStr | The hippocampus and neocortical inhibitory engrams protect against memory interference |
| title_full_unstemmed | The hippocampus and neocortical inhibitory engrams protect against memory interference |
| title_short | The hippocampus and neocortical inhibitory engrams protect against memory interference |
| title_sort | hippocampus and neocortical inhibitory engrams protect against memory interference |
| work_keys_str_mv | AT koolschijnr thehippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT emiru thehippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT pantelidesa thehippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT nilih thehippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT behrenst thehippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT barronh thehippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT koolschijnr hippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT emiru hippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT pantelidesa hippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT nilih hippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT behrenst hippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference AT barronh hippocampusandneocorticalinhibitoryengramsprotectagainstmemoryinterference |