Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive

Chimeric antigen receptor-modified human regulatory T cells that constitutively express IL-10 maintain their phenotype and are potently suppressive

Clinical trials of Treg therapy in transplantation are currently entering phases IIa and IIb, with the majority of these employing polyclonal Treg populations that harbor a broad specificity. Enhancing Treg specificity is possible with the use of chimeric antigen receptors (CARs), which can be custo...

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Bibliographic Details
Main Authors:	Mohseni, YR, Saleem, A, Tung, SL, Dudreiulh, C, Lang, C, Peng, Q, Volpe, A, Adigbli, G, Cross, A, Hester, J, Farzaneh, F, Scotta, C, Lechler, RI, Issa, F, Fruhwirth, GO, Lombardi, G
Format:	Journal article
Language:	English
Published:	Wiley 2021

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