RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting

RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting

<strong>Background: </strong>RH5 is the leading vaccine candidate for the Plasmodium falciparum blood stage and has shown impact on parasite growth in the blood in a human clinical trial. RH5 binds to Ripr and CyRPA at the apical end of the invasive merozoite form, and this complex, desi...

Полное описание

Библиографические подробности
Главные авторы:	Healer, J, Thompson, JK, Mackwell, KL, Browne, CD, Seager, BA, Ngo, A, Lowes, KN, Silk, SE, Pulido, D, King, LDW, Christen, JM, Noe, AR, Kotraiah, V, Masendycz, PJ, Rajagopalan, R, Lucas, L, Stanford, MM, Soisson, L, Diggs, C, Miller, R, Youll, S, Wycherley, K, Draper, SJ, Cowman, AF
Формат:	Journal article
Язык:	English
Опубликовано:	Frontiers Media 2022

Схожие документы

RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting
по: Julie Healer, и др.
Опубликовано: (2022-12-01)

The RH5-CyRPA-Ripr complex as a malaria vaccine target
по: Ragotte, RJ, и др.
Опубликовано: (2020)

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
по: Williams, BG, и др.
Опубликовано: (2024)

Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
по: Barnabas G. Williams, и др.
Опубликовано: (2024-06-01)

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites
по: Knuepfer, E, и др.
Опубликовано: (2019)

Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.
по: Ellen Knuepfer, и др.
Опубликовано: (2019-06-01)

Bliss' and Loewe's additive and synergistic effects in Plasmodium falciparum growth inhibition by AMA1-RON2L, RH5, RIPR and CyRPA antibody combinations
по: Azasi, Y, и др.
Опубликовано: (2020)

Low antibody titers against malaria vaccine candidates RH5, RIPR and CYRPA in naturally infected people in an endemic area of Mali
по: Draper, S, и др.
Опубликовано: (2018)

Expanding the malaria antibody toolkit: development and characterisation of Plasmodium falciparum RH5, CyRPA, and CSP recombinant human monoclonal antibodies
по: Nacer, A, и др.
Опубликовано: (2022)

Expanding the Malaria Antibody Toolkit: Development and Characterisation of Plasmodium falciparum RH5, CyRPA, and CSP Recombinant Human Monoclonal Antibodies
по: Adéla Nacer, и др.
Опубликовано: (2022-06-01)

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA
по: Lin Chen, и др.
Опубликовано: (2017-02-01)

Efficacy of the novel Plasmodium falciparum blood-stage vaccine RH5.1/AS01B in a phase I/IIA clinical trial
по: Minassian, A, и др.
Опубликовано: (2018)

Investigation of the Plasmodium falciparum RH5-Interacting Protein (PfRIPR) as a blood-stage malaria vaccine target
по: Williams, BG
Опубликовано: (2021)

Safety and immunogenicity of the novel plasmodium falciparum blood-stage vaccine RH5.1/AS01B in a phase I/IIA clinical trial
по: Minassian, AM, и др.
Опубликовано: (2017)

Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5.1/AS01B malaria vaccine
по: Nielsen, CM, и др.
Опубликовано: (2023)

In silico T cell epitope prediction identifies high value RH5 epitopes that correlate with response in vaccinees
по: Terry, F, и др.
Опубликовано: (2018)

Delayed boosting improves human antigen-specific Ig and B cell responses to the RH5.1/AS01B malaria vaccine
по: Carolyn M. Nielsen, и др.
Опубликовано: (2023-01-01)

Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody
по: Paola Favuzza, и др.
Опубликовано: (2017-02-01)

Crystal structure of PfRh5, an essential P. falciparum ligand for invasion of human erythrocytes
по: Lin Chen, и др.
Опубликовано: (2014-10-01)

Editorial 5.1
Опубликовано: (2024-05-01)

Editorial 5.1
по: Maria Cristina Triguero Veloz Teixeira
Опубликовано: (2003-01-01)

Créditos 5.1
по: Créditos 5.1
Опубликовано: (2012-02-01)

Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells
по: Jin, J, и др.
Опубликовано: (2018)

Cysteine-Rich Protective Antigen (CyRPA) as promising blood-stage candidate protein for inclusion in a malaria subunit vaccine
по: Favuzza Paola, и др.
Опубликовано: (2012-10-01)

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites
по: Weiss, GE, и др.
Опубликовано: (2023)

The dual action of human antibodies specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking invasion and inactivating extracellular merozoites.
по: Greta E Weiss, и др.
Опубликовано: (2023-09-01)

PHP 5.1 : for beginners /
по: Bayross, Ivan, и др.
Опубликовано: (2006)

5.1. Design as research
по: Jorge Figueira
Опубликовано: (2013-10-01)

ssDNA accessibility of Rad51 is regulated by orchestrating multiple RPA dynamics
по: Jiawei Ding, и др.
Опубликовано: (2023-06-01)

Process development and preclinical evaluation of a major Plasmodium falciparum blood stage vaccine candidate, Cysteine-Rich Protective Antigen (CyRPA)
по: Anjali Somanathan, и др.
Опубликовано: (2022-09-01)

Crosstalk between CST and RPA regulates RAD51 activity during replication stress
по: Kai-Hang Lei, и др.
Опубликовано: (2021-11-01)

Blood-stage malaria vaccine candidate RH5.1/Matrix-M in healthy Tanzanian adults and children; an open-label, non-randomised, first-in-human, single-centre, phase 1b trial
по: Silk, SE, и др.
Опубликовано: (2024)

Bilik Karel 51 : Aras 5

WordPerfect 5.1 for Dos /
по: Maran, Ruth, 1970-
Опубликовано: (1993)

Editor’s Note: Issue 5.1
по: Eric Murphy Selinger
Опубликовано: (2015-08-01)

The role of GnRH metabolite, GnRH-(1-5), in endometrial cancer
по: Madelaine J. Cho-Clark, и др.
Опубликовано: (2023-04-01)

Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions.
по: Payne, RO, и др.
Опубликовано: (2017)

Characterizing the plasma IgG antibody repertoire of malaria-naïve United Kingdom adults vaccinated with novel blood stage vaccine RH5.1/AS01 B
по: Marchioni, J, и др.
Опубликовано: (2023)

Gálatas 5,1-6: a vocação para a liberdade = Galatians 5,1-6: the call to freedom = Gálatas 5,1-6: la llamada a la libertad
по: Gonzaga, Waldecir
Опубликовано: (2023-01-01)

Antibodies from malaria-exposed Malians generally interact additively or synergistically with human vaccine-induced RH5 antibodies
по: Willcox, AC, и др.
Опубликовано: (2021)