Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.

Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.

The transcription factor Runx1/AML1 is an important regulator of hematopoiesis and is critically required for the generation of the first definitive hematopoietic stem cells (HSCs) in the major vasculature of the mouse embryo. As a pivotal factor in HSC ontogeny, its transcriptional regulation is of...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Nottingham, W, Jarratt, A, Burgess, M, Speck, C, Cheng, J, Prabhakar, S, Rubin, E, Li, P, Sloane-Stanley, J, Kong-A-San, J, de Bruijn, M
التنسيق:	Journal article
اللغة:	English
منشور في:	2007

مواد مشابهة

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Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1 expression during embryonic blood development.
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Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development
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منشور في: (2022-02-01)

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo
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CBFβ initiates the hematopoietic stem cell program without obligatory binding to RUNX
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Regulation of the stem cell leukemia (SCL) gene: a tale of two fishes.
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Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
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Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD
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Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis.
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منشور في: (2003)

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The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.
حسب: Lécuyer, E, وآخرون
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Discovering Regulatory SNPs by Genome-Wide Analysis of Differential Scl/TAL-1 Occupancy in Human Primary Erythroid Cells
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The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.
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Dioramas SCL2110
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A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.
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