Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.

Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer.

The transcription factor Runx1/AML1 is an important regulator of hematopoiesis and is critically required for the generation of the first definitive hematopoietic stem cells (HSCs) in the major vasculature of the mouse embryo. As a pivotal factor in HSC ontogeny, its transcriptional regulation is of...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Nottingham, W, Jarratt, A, Burgess, M, Speck, C, Cheng, J, Prabhakar, S, Rubin, E, Li, P, Sloane-Stanley, J, Kong-A-San, J, de Bruijn, M
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2007

Παρόμοια τεκμήρια

The mouse Runx1 +23 hematopoietic stem cell enhancer confers hematopoietic specificity to both Runx1 promoters.
ανά: Bee, T, κ.ά.
Έκδοση: (2009)

An intronic Runx1 enhancer directs transcription to the emerging hematopoietic system of the mouse embryo
ανά: Nottingham, W, κ.ά.
Έκδοση: (2007)

Hematopoietic stem cell emergence in the conceptus and the role of Runx1.
ανά: Swiers, G, κ.ά.
Έκδοση: (2010)

Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.
ανά: Landry, JR, κ.ά.
Έκδοση: (2008)

DISTINCT RUNX1 ENHANCERS DIRECT TRANSCRIPTION TO DISCRETE STAGES OF DEVELOPMENTAL HEMATOPOIESIS
ανά: O'Rourke, J, κ.ά.
Έκδοση: (2012)

Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche
ανά: Fitch, SR, κ.ά.
Έκδοση: (2019)

The SCL transcriptional network and BMP signaling pathway interact to regulate RUNX1 activity.
ανά: Pimanda, J, κ.ά.
Έκδοση: (2007)

Runx1 is expressed in adult mouse hematopoietic stem cells and differentiating myeloid and lymphoid cells, but not in maturing erythroid cells.
ανά: North, T, κ.ά.
Έκδοση: (2004)

Genome-wide computational screen for bloon stem cell enhancers integrates RUNX1 and the BMP signaling pathway into the SCL transcriptional network
ανά: Pimanda, J, κ.ά.
Έκδοση: (2007)

Runx1 loss minimally impacts long-term hematopoietic stem cells.
ανά: Xiongwei Cai, κ.ά.
Έκδοση: (2011-01-01)

Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.
ανά: Göttgens, B, κ.ά.
Έκδοση: (2002)

Using RUNX1 enhancer-reporter transgenic mouse models to dissect discrete stages of developmental hematopoiesis
ανά: Rode, C, κ.ά.
Έκδοση: (2014)

Alternative Runx1 promoter usage in mouse developmental hematopoiesis.
ανά: Bee, T, κ.ά.
Έκδοση: (2009)

Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells
ανά: Yoshiki Omatsu, κ.ά.
Έκδοση: (2022-05-01)

Locus-wide studies into the transcriptional regulation of Runx1 in developmental hematopoiesis
ανά: Jarratt, A
Έκδοση: (2012)

From hemangioblast to hematopoietic stem cell: an endothelial connection?
ανά: Jaffredo, T, κ.ά.
Έκδοση: (2005)

Identification of critical residues for the function of the bHLH transcription factor SCL in hematopoietic stem cells.
ανά: Porcher, C, κ.ά.
Έκδοση: (2003)

Haploinsufficiency of GATA-2 perturbs adult hematopoietic stem-cell homeostasis.
ανά: Rodrigues, N, κ.ά.
Έκδοση: (2005)

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development
ανά: Owens, DDG, κ.ά.
Έκδοση: (2022)

GATA3 is redundant for maintenance and self-renewal of hematopoietic stem cells.
ανά: Buza-Vidas, N, κ.ά.
Έκδοση: (2011)

Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1 expression during embryonic blood development.
ανά: Walmsley, M, κ.ά.
Έκδοση: (2008)

THE RUNX1+23 ENHANCER IS ACTIVE IN CELLS WITH BOTH ENDOTHELIAL AND HEMATOPOIETIC CHARACTERISTICS DURING MOUSE DEVELOPMENTAL HEMATOPOIESIS
ανά: Swiers, G, κ.ά.
Έκδοση: (2009)

Dynamic Runx1 chromatin boundaries affect gene expression in hematopoietic development
ανά: Dominic D. G. Owens, κ.ά.
Έκδοση: (2022-02-01)

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo
ανά: Zaniah N. Gonzalez Galofre, κ.ά.
Έκδοση: (2024-02-01)

CBFβ initiates the hematopoietic stem cell program without obligatory binding to RUNX
ανά: Aldo Ciau-Uitz, κ.ά.
Έκδοση: (2017)

Regulation of the stem cell leukemia (SCL) gene: a tale of two fishes.
ανά: Barton, L, κ.ά.
Έκδοση: (2001)

Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.
ανά: Schlaeger, T, κ.ά.
Έκδοση: (2004)

Hematopoietic Cell Autonomous Disruption of Hematopoiesis in a Germline Loss-of-function Mouse Model of RUNX1-FPD
ανά: Martijn P. T. Ernst, κ.ά.
Έκδοση: (2023-02-01)

Twist1 regulates embryonic hematopoietic differentiation through binding to Myb and Gata2 promoter regions
ανά: Kasem Kulkeaw, κ.ά.
Έκδοση: (2017-09-01)

Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis.
ανά: Bee, T, κ.ά.
Έκδοση: (2010)

Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of Gata1.
ανά: Gering, M, κ.ά.
Έκδοση: (2003)

Transient Expression of GATA3 in Hematopoietic Stem Cells Facilitates Helper Innate Lymphoid Cell Differentiation
ανά: Dejene M. Tufa, κ.ά.
Έκδοση: (2019-03-01)

RUNX1 Mutations in Inherited and Sporadic Leukemia
ανά: Dana C. Bellissimo, κ.ά.
Έκδοση: (2017-12-01)

The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1.
ανά: Lécuyer, E, κ.ά.
Έκδοση: (2002)

Discovering Regulatory SNPs by Genome-Wide Analysis of Differential Scl/TAL-1 Occupancy in Human Primary Erythroid Cells
ανά: De Gobbi, M, κ.ά.
Έκδοση: (2011)

The LMO2 -25 Region Harbours GATA2-Dependent Myeloid Enhancer and RUNX-Dependent T-Lymphoid Repressor Activity.
ανά: Nicolas Bonadies, κ.ά.
Έκδοση: (2015-01-01)

A RUNX1-SMAD6 RHEOSTAT CONTROLS RUNX1 LEVELS AND REGULATES HEMATOPOIESIS IN THE DEVELOPING EMBRYO
ανά: Pimanda, J, κ.ά.
Έκδοση: (2010)

High GATA-2 expression inhibits human hematopoietic stem and progenitor cell function by effects on cell cycle.
ανά: Tipping, A, κ.ά.
Έκδοση: (2009)

Dioramas SCL2110
ανά: Rodrigo Tisi
Έκδοση: (2012-04-01)

A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.
ανά: Knezevic, K, κ.ά.
Έκδοση: (2011)