miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma.
Micro-RNAs are a group of small noncoding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression of mature micro-RNAs in human cancers. We characterized the alteration in expression of miR-29b in ovarian serous carcinoma. miR-29b expression was analyzed using quan...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1826298072716541952 |
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| author | Flavin, R Smyth, P Barrett, C Russell, S Wen, H Wei, J Laios, A O'Toole, S Ring, M Denning, K Li, J Aherne, S Sammarae, D Aziz, N Alhadi, A Finn, S Loda, M B, S Sheils, O O'Leary, J |
| author_facet | Flavin, R Smyth, P Barrett, C Russell, S Wen, H Wei, J Laios, A O'Toole, S Ring, M Denning, K Li, J Aherne, S Sammarae, D Aziz, N Alhadi, A Finn, S Loda, M B, S Sheils, O O'Leary, J |
| author_sort | Flavin, R |
| collection | OXFORD |
| description | Micro-RNAs are a group of small noncoding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression of mature micro-RNAs in human cancers. We characterized the alteration in expression of miR-29b in ovarian serous carcinoma. miR-29b expression was analyzed using quantitative stem-loop reverse transcriptase polymerase chain reaction on a set of 50 formalin-fixed, paraffin-embedded ovarian serous carcinoma samples. Protein expression of p53, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, and insulinlike growth factor 1 was quantified in the corresponding tissue microarray. The expression profile of miR-29b was correlated with clinicopathological and patient survival data. We provide definitive evidence that miR-29b is down-regulated in a significant proportion of ovarian serous carcinomas and is associated with specific clinicopathological features, most notably high miR-29b expression being associated with reduced disease-free survival. |
| first_indexed | 2024-03-07T04:41:15Z |
| format | Journal article |
| id | oxford-uuid:d1bb50ed-938a-448f-95e1-1d66ca09240a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:41:15Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:d1bb50ed-938a-448f-95e1-1d66ca09240a2022-03-27T07:58:57ZmiR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d1bb50ed-938a-448f-95e1-1d66ca09240aEnglishSymplectic Elements at Oxford2009Flavin, RSmyth, PBarrett, CRussell, SWen, HWei, JLaios, AO'Toole, SRing, MDenning, KLi, JAherne, SSammarae, DAziz, NAlhadi, AFinn, SLoda, MB, SSheils, OO'Leary, JMicro-RNAs are a group of small noncoding RNAs approximately 22 nucleotides in length. Recent work has shown differential expression of mature micro-RNAs in human cancers. We characterized the alteration in expression of miR-29b in ovarian serous carcinoma. miR-29b expression was analyzed using quantitative stem-loop reverse transcriptase polymerase chain reaction on a set of 50 formalin-fixed, paraffin-embedded ovarian serous carcinoma samples. Protein expression of p53, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, and insulinlike growth factor 1 was quantified in the corresponding tissue microarray. The expression profile of miR-29b was correlated with clinicopathological and patient survival data. We provide definitive evidence that miR-29b is down-regulated in a significant proportion of ovarian serous carcinomas and is associated with specific clinicopathological features, most notably high miR-29b expression being associated with reduced disease-free survival. |
| spellingShingle | Flavin, R Smyth, P Barrett, C Russell, S Wen, H Wei, J Laios, A O'Toole, S Ring, M Denning, K Li, J Aherne, S Sammarae, D Aziz, N Alhadi, A Finn, S Loda, M B, S Sheils, O O'Leary, J miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma. |
| title | miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma. |
| title_full | miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma. |
| title_fullStr | miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma. |
| title_full_unstemmed | miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma. |
| title_short | miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma. |
| title_sort | mir 29b expression is associated with disease free survival in patients with ovarian serous carcinoma |
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