Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.

Dengue virus presents a growing threat to public health in the developing world. Four major serotypes of dengue virus have been characterized, and epidemiological evidence shows that dengue hemorrhagic fever (DHF), the more serious manifestation of the disease, occurs more frequently upon reinfectio...

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Main Authors: Mongkolsapaya, J, Dejnirattisai, W, Xu, X, Vasanawathana, S, Tangthawornchaikul, N, Chairunsri, A, Sawasdivorn, S, Duangchinda, T, Dong, T, Rowland-Jones, S, Yenchitsomanus, P, McMichael, A, Malasit, P, Screaton, G
Format: Journal article
Language:English
Published: 2003
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author Mongkolsapaya, J
Dejnirattisai, W
Xu, X
Vasanawathana, S
Tangthawornchaikul, N
Chairunsri, A
Sawasdivorn, S
Duangchinda, T
Dong, T
Rowland-Jones, S
Yenchitsomanus, P
McMichael, A
Malasit, P
Screaton, G
author_facet Mongkolsapaya, J
Dejnirattisai, W
Xu, X
Vasanawathana, S
Tangthawornchaikul, N
Chairunsri, A
Sawasdivorn, S
Duangchinda, T
Dong, T
Rowland-Jones, S
Yenchitsomanus, P
McMichael, A
Malasit, P
Screaton, G
author_sort Mongkolsapaya, J
collection OXFORD
description Dengue virus presents a growing threat to public health in the developing world. Four major serotypes of dengue virus have been characterized, and epidemiological evidence shows that dengue hemorrhagic fever (DHF), the more serious manifestation of the disease, occurs more frequently upon reinfection with a second serotype. We have studied dengue virus-specific T-cell responses in Thai children. During acute infection, few dengue-responsive CD8+ T cells were recovered; most of those present showed an activated phenotype and were undergoing programmed cell death. Many dengue-specific T cells were of low affinity for the infecting virus and showed higher affinity for other, probably previously encountered strains. Profound T-cell activation and death may contribute to the systemic disturbances leading to DHF, and original antigenic sin in the T-cell responses may suppress or delay viral elimination, leading to higher viral loads and increased immunopathology.
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spelling oxford-uuid:d1bd9565-0e50-4a8e-a75a-90522dbda04c2022-03-27T07:59:08ZOriginal antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d1bd9565-0e50-4a8e-a75a-90522dbda04cEnglishSymplectic Elements at Oxford2003Mongkolsapaya, JDejnirattisai, WXu, XVasanawathana, STangthawornchaikul, NChairunsri, ASawasdivorn, SDuangchinda, TDong, TRowland-Jones, SYenchitsomanus, PMcMichael, AMalasit, PScreaton, GDengue virus presents a growing threat to public health in the developing world. Four major serotypes of dengue virus have been characterized, and epidemiological evidence shows that dengue hemorrhagic fever (DHF), the more serious manifestation of the disease, occurs more frequently upon reinfection with a second serotype. We have studied dengue virus-specific T-cell responses in Thai children. During acute infection, few dengue-responsive CD8+ T cells were recovered; most of those present showed an activated phenotype and were undergoing programmed cell death. Many dengue-specific T cells were of low affinity for the infecting virus and showed higher affinity for other, probably previously encountered strains. Profound T-cell activation and death may contribute to the systemic disturbances leading to DHF, and original antigenic sin in the T-cell responses may suppress or delay viral elimination, leading to higher viral loads and increased immunopathology.
spellingShingle Mongkolsapaya, J
Dejnirattisai, W
Xu, X
Vasanawathana, S
Tangthawornchaikul, N
Chairunsri, A
Sawasdivorn, S
Duangchinda, T
Dong, T
Rowland-Jones, S
Yenchitsomanus, P
McMichael, A
Malasit, P
Screaton, G
Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.
title Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.
title_full Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.
title_fullStr Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.
title_full_unstemmed Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.
title_short Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.
title_sort original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever
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