A universally conserved residue in the SUR1 subunit of the K ATP channel is essential for translating nucleotide binding at SUR1 into channel opening

A universally conserved residue in the SUR1 subunit of the K ATP channel is essential for translating nucleotide binding at SUR1 into channel opening

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The sulphonylurea receptor (SUR1) subunit of the ATP-sensitive potassium (K ATP) channel is a member of the ATP-binding cassette (ABC) protein family. Binding of MgADP to nucleotide-binding domain 2 (NBD2) is critical for channel activation. We identified a residue in NBD2 (G1401) that is fully cons...

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Bibliographic Details
Main Authors: de Wet, H, Shimomura, K, Aittoniemi, J, Ahmad, N, Lafond, M, Sansom, MS, Ashcroft, F
Format: Journal article
Language:English
Published: 2012

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