The CST complex mediates end protection at double-strand breaks and promotes PARP inhibitor sensitivity in BRCA1-deficient cells

The CST complex mediates end protection at double-strand breaks and promotes PARP inhibitor sensitivity in BRCA1-deficient cells

Selective elimination of BRCA1-deficient cells by inhibitors of poly(ADP-ribose) polymerase (PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This interaction is counteracted by the restoration of BRCA1-independent homologous recombination through loss of factors suc...

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Hlavní autoři: Barazas, M, Annunziato, S, Pettitt, S, de Krijger, I, Ghezraoui, H, Roobol, S, Lutz, C, Frankum, J, Song, F, Brough, R, Evers, B, Gogola, E, Bhin, J, van de Ven, M, van Gent, D, Jacobs, J, Chapman, J, Lord, C, Jonkers, J, Rottenberg, S
Médium: Journal article
Jazyk:English
Vydáno: Elsevier 2018

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