Epigenetic silencing of RASSF1A promotes tumourigenesis via alternative transcript expression, SFK activation and exosome secretion
<p>Loss of the tumour-suppressor gene <em>RASSF1A</em> upon promoter methylation is one of the most frequent events in sporadic human malignancies. Loss of RASSF1A is associated with progression and pathogenesis of solid tumours; and more aggressive clinical phenotype, leading to p...
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| Format: | Thesis |
| Language: | English |
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2015
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