Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes

Direct catalytic asymmetric synthesis of α-chiral bicyclo[1.1.1]pentanes

Bicyclo[1.1.1]pentanes (BCPs) are important motifs in contemporary drug design as linear spacer units that improve pharmacokinetic profiles. The synthesis of BCPs featuring adjacent stereocenters is highly challenging, but desirable due to the fundamental importance of 3D chemical space in medicinal...

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Bibliographic Details
Main Authors:	Wong, MLJ, Sterling, AJ, Mousseau, JJ, Duarte Gonzalez, FJ, Anderson, EA
Format:	Journal article
Language:	English
Published:	Springer Nature 2021

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