CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis.
UNLABELLED: Recently, a new subtype of limbic encephalitis (LE) has been described, serologically characterized by the presence of antibodies against voltage gated potassium channels (VGKC, to be called VGKC-LE). Only little is known about CSF findings in this new disorder. Here we report the result...
| Κύριοι συγγραφείς: | , , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
2008
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| _version_ | 1826298120653242368 |
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| author | Jarius, S Hoffmann, L Clover, L Vincent, A Voltz, R |
| author_facet | Jarius, S Hoffmann, L Clover, L Vincent, A Voltz, R |
| author_sort | Jarius, S |
| collection | OXFORD |
| description | UNLABELLED: Recently, a new subtype of limbic encephalitis (LE) has been described, serologically characterized by the presence of antibodies against voltage gated potassium channels (VGKC, to be called VGKC-LE). Only little is known about CSF findings in this new disorder. Here we report the results of 29 lumbar punctures in 17 patients with VGKC-LE. Slight pleocytosis, mainly consisting of lymphocytes and monocytes, and elevated total protein concentrations were present in 41 and 47%, respectively. Intrathecal immunoglobulin (Ig) synthesis as defined by the presence of CSF-specific oligoclonal IgG bands, an increased IgG index, or an elevated IgG, IgA, or IgM ratio, was not detected in any of the patients, but dysfunction of the blood-CSF barrier was found in 35%. CSF findings were normal in 23%. CONCLUSIONS: Unlike paraneoplastic LE, VGKC-LE is not frequently associated with intrathecal Ig production or markedly elevated white cell counts. Thus, normal CSF findings do not preclude the disease. VGKC-Ab should, therefore, be determined whenever LE is clinically suspected, irrespective of the presence or absence of inflammatory CSF changes. |
| first_indexed | 2024-03-07T04:42:00Z |
| format | Journal article |
| id | oxford-uuid:d1f6f975-d719-4031-a56b-bc42bb0a7956 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:42:00Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:d1f6f975-d719-4031-a56b-bc42bb0a79562022-03-27T08:00:33ZCSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d1f6f975-d719-4031-a56b-bc42bb0a7956EnglishSymplectic Elements at Oxford2008Jarius, SHoffmann, LClover, LVincent, AVoltz, RUNLABELLED: Recently, a new subtype of limbic encephalitis (LE) has been described, serologically characterized by the presence of antibodies against voltage gated potassium channels (VGKC, to be called VGKC-LE). Only little is known about CSF findings in this new disorder. Here we report the results of 29 lumbar punctures in 17 patients with VGKC-LE. Slight pleocytosis, mainly consisting of lymphocytes and monocytes, and elevated total protein concentrations were present in 41 and 47%, respectively. Intrathecal immunoglobulin (Ig) synthesis as defined by the presence of CSF-specific oligoclonal IgG bands, an increased IgG index, or an elevated IgG, IgA, or IgM ratio, was not detected in any of the patients, but dysfunction of the blood-CSF barrier was found in 35%. CSF findings were normal in 23%. CONCLUSIONS: Unlike paraneoplastic LE, VGKC-LE is not frequently associated with intrathecal Ig production or markedly elevated white cell counts. Thus, normal CSF findings do not preclude the disease. VGKC-Ab should, therefore, be determined whenever LE is clinically suspected, irrespective of the presence or absence of inflammatory CSF changes. |
| spellingShingle | Jarius, S Hoffmann, L Clover, L Vincent, A Voltz, R CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis. |
| title | CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis. |
| title_full | CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis. |
| title_fullStr | CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis. |
| title_full_unstemmed | CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis. |
| title_short | CSF findings in patients with voltage gated potassium channel antibody associated limbic encephalitis. |
| title_sort | csf findings in patients with voltage gated potassium channel antibody associated limbic encephalitis |
| work_keys_str_mv | AT jariuss csffindingsinpatientswithvoltagegatedpotassiumchannelantibodyassociatedlimbicencephalitis AT hoffmannl csffindingsinpatientswithvoltagegatedpotassiumchannelantibodyassociatedlimbicencephalitis AT cloverl csffindingsinpatientswithvoltagegatedpotassiumchannelantibodyassociatedlimbicencephalitis AT vincenta csffindingsinpatientswithvoltagegatedpotassiumchannelantibodyassociatedlimbicencephalitis AT voltzr csffindingsinpatientswithvoltagegatedpotassiumchannelantibodyassociatedlimbicencephalitis |