HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes.
Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the virus nucleoprotein on infected cells. CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence...
| Main Authors: | , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
1986
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| _version_ | 1826298135181262848 |
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| author | Mcmichael, A Gotch, F Rothbard, J |
| author_facet | Mcmichael, A Gotch, F Rothbard, J |
| author_sort | Mcmichael, A |
| collection | OXFORD |
| description | Human influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the virus nucleoprotein on infected cells. CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence. Influenza-specific CTL from 10 donors of other HLA types failed to recognize this epitope. CD8+ CTL lines were derived from lymphocytes of two HLA B37-positive donors and used to show that the peptide was represented on virus-infected cells and to determine the probable boundaries of the epitope. |
| first_indexed | 2024-03-07T04:42:13Z |
| format | Journal article |
| id | oxford-uuid:d20caa42-e329-4ce8-86df-cfea0043e8d6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T04:42:13Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:d20caa42-e329-4ce8-86df-cfea0043e8d62022-03-27T08:01:03ZHLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:d20caa42-e329-4ce8-86df-cfea0043e8d6EnglishSymplectic Elements at Oxford1986Mcmichael, AGotch, FRothbard, JHuman influenza A virus-specific, cytotoxic T cells have been shown previously to recognize the virus nucleoprotein on infected cells. CTL preparations from four HLA B37-positive donors were shown to recognize a synthetic peptide that corresponded to amino acids 335-349 of the nucleoprotein sequence. Influenza-specific CTL from 10 donors of other HLA types failed to recognize this epitope. CD8+ CTL lines were derived from lymphocytes of two HLA B37-positive donors and used to show that the peptide was represented on virus-infected cells and to determine the probable boundaries of the epitope. |
| spellingShingle | Mcmichael, A Gotch, F Rothbard, J HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes. |
| title | HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes. |
| title_full | HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes. |
| title_fullStr | HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes. |
| title_full_unstemmed | HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes. |
| title_short | HLA B37 determines an influenza A virus nucleoprotein epitope recognized by cytotoxic T lymphocytes. |
| title_sort | hla b37 determines an influenza a virus nucleoprotein epitope recognized by cytotoxic t lymphocytes |
| work_keys_str_mv | AT mcmichaela hlab37determinesaninfluenzaavirusnucleoproteinepitoperecognizedbycytotoxictlymphocytes AT gotchf hlab37determinesaninfluenzaavirusnucleoproteinepitoperecognizedbycytotoxictlymphocytes AT rothbardj hlab37determinesaninfluenzaavirusnucleoproteinepitoperecognizedbycytotoxictlymphocytes |